Soo saaraha budada CMS121 Lambarka CAS: 1353224-53-9 98.0% daahirnimo ugu yaraan maaddooyinka dheeraadka ah
Cabbiraadaha Badeecada
| Magaca alaabta | CMS121 |
| Magac kale | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC, AcetylCoenzymeACarboxylase, cudur, difaac neerfaha, joojiya, ka hortagga bararka, mitochondrial, Alzheimer's, antioxidative, acetylation, Inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, waallida, ACC1, CMS-121 |
| Lambarka CAS. | 1353224-53-9 |
| Qaacidada moolikaalka | C20H19NO3 |
| Miisaanka molecular-ka | 321.37 |
| Daahirnimo | 98.0% |
| Muuqaalka | Budada jaalaha ah ee khafiifka ah |
| Codsiga | Qalabka Cuntada ee Cayriin ah |
Soo bandhigida badeecada
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol waa isku-dhis sidoo kale loo yaqaan CMS121. Kakanaanta qaab-dhismeedka isku-dhisku waxay soo jeedinaysaa inay yeelan karto sifooyin gaar ah iyo isticmaal suurtagal ah. Si loo fahmo muhiimaddeeda, waxay ka caawisaa in la aqoonsado kooxaha shaqeynaya ee jira iyo in la falanqeeyo saameyntooda suurtagalka ah. Joogitaanka giraanta quinoline waxay soo jeedinaysaa in isku-dhisku uu noqon karo mid firfircoon oo bayooloji ah. Molecules-ka laga soo qaatay Quinoline waxaa loo yaqaanaa sifooyinkooda bayooloji ee kala duwan, oo ay ku jiraan hawlaha bakteeriyada dila iyo ka hortagga bararka. Ku-xidhnaanta kooxda cyclopentyloxy waxay gacan ka geysan kartaa milmida isku-darka ama waxay kor u qaadi kartaa dhaqdhaqaaqeeda bayoolojiga iyada oo loo marayo saameynta steric. Daraasadaha ku saabsan unugyada HT22, CMS-121 waxay muujisay saameyno muhiim ah oo neerfaha ilaaliya, iyadoo si wax ku ool ah uga ilaalinaysa unugyadan ischemia iyo waxyeelada oksaydhka. Intaa waxaa dheer, CMS-121 waxay leedahay sifooyin muhiim ah oo ka hortagga bararka, taasoo muujinaysa awooddeeda ay ku beddeli karto jawaabaha bararka. Marka sidaas la sameeyo, CMS-121 waxay leedahay awood ay ku yareyso bararka unugyada iyo xubnaha kala duwan. CMS-121 waxay leedahay firfircooni xooggan oo daawo ahaan ah oo ka hortagta acetyl-CoA carboxylase 1 (ACC1). Saamaynteeda xakamaynta xooggan ee ACC1 waxay ka dhigaysaa isku-darka rajo leh.
Muuqaalka
(1) Nadiifnimo sare: CMS-121 waxay heli kartaa badeecooyin saafi ah iyada oo loo marayo hababka wax soo saarka ee la safeeyey. Nadiifnimo sare macnaheedu waa helitaan wanaagsan oo noolaha ah iyo falcelin xun oo yar.
(2) Badbaadada: Badbaado sare, falcelin xun oo yar.
(3) Xasillooni: CMS-121 waxay leedahay xasillooni wanaagsan waxayna ilaalin kartaa dhaqdhaqaaqeeda iyo saameynteeda iyadoo la raacayo jawiyo iyo xaalado kaydin oo kala duwan.
Codsiyada
CMS-121 waa daawo ka soo jeeda quinolone iyo acetyl-CoA carboxylase 1 (ACC1) oo afka laga qaato oo leh sifooyin dawooyin oo rajo leh. Cilmi-baaris ballaaran ayaa la sameeyay si loo baaro faa'iidooyinka suurtagalka ah ee CMS-121 ee meelo kala duwan, oo ay ku jiraan ilaalinta neerfaha, saamaynta ka hortagga bararka, dhaqdhaqaaqa antioxidant-ka, iyo saameynta ay ku leedahay calaamadaha la xiriira gabowga caafimaadka qaba.
