1,4-DihydronicotinaMide Riboside soo saaraha budada CAS No.:19132-12-8 98% daahirnimo ugu yaraan maaddooyinka dheeraadka ah
Cabbiraadaha Badeecada
| Magaca alaabta | 1,4-DihydronicotinaMide Riboside |
| Magac kale | 1,4-DIHYDRONICOTINAMIDE RIBOSIDE1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,4-dihydropyridine-3-carboxamideSCHEMBL188493711-[(3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-4H-PYRIDINE-3-CARBOXAMIDE |
| Lambarka CAS. | 19132-12-8 |
| Qaacidada moolikaalka | C11H16N2O5 |
| Miisaanka molecular-ka | 256.26 |
| Daahirnimo | 98% |
| Muuqaalka | Budada cad |
| Baakad | 1kg/bac;25kg/durbaan |
| Codsiga | Alaabta ceeriin ee dheeraadka cuntada |
Soo bandhigida badeecada
1,4-dihydronicotinamide riboside, oo sidoo kale loo yaqaan NRH.Nooca NRH ee yaraada waa horudhac NAD+ oo awood leh kaas oo gacan ka geysta dib u buuxinta heerarkeeda unugga.
Marka ugu horreysa, waa muhiim in la fahmo doorka NAD+ ee jirka. NAD+ waa coenzyme oo ku lug leh habab badan oo unugyo ah, oo ay ku jiraan dheef-shiid kiimikaadka tamarta, hagaajinta DNA-da, iyo muujinta hidda-wadaha. Marka aan gabowno, heerarka NAD+ hoos ayay u dhacaan, taas oo lagu lug lahaa habka gabowga iyo cudurrada la xiriira da'da. Tani waxay keentay xiiso sii kordheysa oo lagu ogaanayo molecules-ka kor u qaadi kara heerarka NAD+ ee jirka, iyo 1,4-dihydronicotinamide riboside waa mid ka mid ah molecules-kaas.
Riboside 1,4-dihydronicotinamide waa horudhac NAD+ oo awood leh, cilmi-baaristuna waxay muujisay inay si wax ku ool ah kor ugu qaadi karto heerarka NAD+ ee unugyada. Tani waxay keentay mala-awaal ah in kaabista riboside ee 1,4-dihydronicotinamide ay yeelan karto awood daaweyn xaalado caafimaad oo kala duwan, oo ay ku jiraan cilladaha dheef-shiid kiimikaadka, cudurrada neerfaha, iyo hoos u dhaca la xiriira gabowga.
Xaqiiqdii, waxaa jira caddaymo muujinaya in riboside 1,4-dihydronicotinamide uu ka waxtar badan yahay molecule-kiisa waalidka, nicotinamide riboside, marka la kordhiyo heerarka NAD+. Tani waa sababta oo ah riboside 1,4-dihydronicotinamide waa mid aad u awood badan, taasoo la macno ah inay ka fiican tahay ku deeqida elektaroonada marinnada isku-darka NAD+. Natiijo ahaan, waxay leedahay awood ay si hufan ugu shidaaliso wax soo saarka unugyada NAD+.
Marka laga soo tago doorkeeda ku aaddan biosynthesis-ka NAD+, riboside-ka 1,4-dihydronicotinamide wuxuu kaloo leeyahay sifooyin antioxidant ah. Walwalka oksaydhka, kaas oo ka dhasha dheelitir la'aanta u dhaxaysa xagjirrada xorta ah iyo antioxidants-ka jirka, ayaa ku lug leh cuduro badan, oo ay ku jiraan kansarka, cudurrada wadnaha iyo xididdada dhiigga, iyo khalkhalka neerfaha. Iyada oo la baabi'inayo xagjirrada xorta ah iyo yareynta waxyeelada oksaydhka, riboside-ka 1,4-dihydronicotinamide wuxuu bixin karaa faa'iidooyin caafimaad oo dheeraad ah oo ka baxsan doorkiisa horudhaca NAD+.
Muuqaalka
(1) Nadiifnimo sare: 1,4-dihydronicotinamide riboside wuxuu heli karaa badeecooyin saafi ah iyada oo loo marayo hababka wax soo saarka ee la safeeyey. Nadiifnimo sare macnaheedu waa helitaan wanaagsan oo noolaha ah iyo falcelin xun oo yar.
(2) Badbaadada: 1,4-dihydronicotinamide riboside waa badeeco dabiici ah oo la xaqiijiyay inay ammaan u tahay jirka aadanaha.
(3) Xasillooni: 1,4-dihydronicotinamide riboside waxay leedahay xasillooni wanaagsan waxayna ilaalin kartaa firfircoonideeda iyo saameynteeda iyadoo la raacayo jawiyo iyo xaalado kaydin oo kala duwan.
Codsiyada
1,4-Dihydronicotinamide waa nooca la dhimay ee nicotinamide riboside. Waxay ku jiri kartaa qaabab oksaydhaysan iyo kuwo la dhimay labadaba waana horudhac u ah NAD cusub oo la helay (nicotinamide adenine dinucleotide), oo loo heli karo kaabis ahaan, iyadoo NRH ay tahay horudhac NAD+ oo ka awood badan kana dhakhso badan NR.
