Soo saaraha budada Lemairamin (WGX-50) Lambarka CAS: 29946-61-0 98.0% daahirnimo ugu yaraan maaddooyinka dheeraadka ah
Fiidiyowga Badeecada
Cabbiraadaha Badeecada
| Magaca alaabta | Lemairamin |
| Magac kale | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| Lambarka CAS. | 29946-61-0 |
| Qaacidada moolikaalka | C19H21NO3 |
| Miisaanka molecular-ka | 311.37 |
| Daahirnimo | 98.0% |
| Muuqaalka | Budada cad ilaa budo cad |
| Codsiga | Qalabka Cuntada ee Cayriin ah |
Soo bandhigida badeecada
Lemairamin ama Wgx50 waa iskudhis dabiici ah oo laga soo saaray basbaaska basbaaska kaas oo muujiyay natiijooyin rajo leh oo ka hortagga cudurka Alzheimers. Daraasado ayaa lagu ogaaday inuu joojin karo apoptosis-ka neerfaha ee uu keeno Aβ, uu yareyn karo sunta kaalshiyamka neerfaha, iyo inuu yareeyo ururinta oligomers-ka Aβ ee ku jira kiliyaha maskaxda. Intaa waxaa dheer, wgx50 waxaa la muujiyay inuu hagaajiyo waxqabadka garashada ee jiirka. Cilmi-baaristu waxay soo jeedinaysaa in wgx50 uu leeyahay awood uu kaga hortago isu-imaatinka borotiinka-borotiin ee u dhexeeya molecules-ka amyloid. Guud ahaan, wgx50 wuxuu leeyahay awood uu kaga hortago cudurka Alzheimers wuxuuna bixin karaa waddooyin cusub oo lagu horumarinayo daawooyinka bartilmaameedsanaya oligomers-ka Aβ. Intaa waxaa dheer, WGX-50 wuxuu muujiyaa firfircooni ka hortag barar oo muhiim ah, taasoo ka dhigaysa musharax rajo leh oo loogu talagalay daaweynta cudurrada bararka. WGX-50 waxaa la ogaaday inay leeyihiin saameyn weyn oo ku saabsan maqaarka, sida yareynta laalaabyada iyo hagaajinta dabacsanaanta maqaarka. Marka laga soo tago iskudhisyada dabiiciga ah ee laga soo saaro geedka Zanthoxylum bungeanum, waxaa hadda jira iskudhisyo badan oo macmal ah oo loo isticmaalo codsiyo kala duwan waxayna ku habboon yihiin suuqa.
Muuqaalka
(1) Nadiifnimo sare: Lemairamin wuxuu heli karaa badeecooyin saafi ah oo heer sare ah iyada oo loo marayo soo saarista dabiiciga ah iyo hababka wax soo saarka ee sifeynta. Nadiifnimo sare waxay ka dhigan tahay helitaan wanaagsan oo noolaha ah iyo falcelin xun oo yar.
(2) Badbaadada: Badbaado sare, falcelin xun oo yar, falcelin xun oo muuqata ma jiraan xitaa isticmaalka muddada dheer.
(3) Xasillooni: Lemairamin waxay leedahay xasillooni wanaagsan waxayna ilaalin kartaa firfircoonideeda iyo saameynteeda iyadoo la raacayo jawiyo iyo xaalado kaydin oo kala duwan.
(4) Si Fudud Loo Nuugo: Lemairamin waxaa si dhakhso ah u nuugi kara jidhka bini'aadamka waxaana loo qaybin karaa unugyo iyo xubno kala duwan.
Codsiyada
Lemairamin waa isku-darka amide ee laga soo saaray jilifka geedka Zanthoxylum bungeanum. Hadda waxaa loo isticmaalaa kabitaan cunto, waxay sidoo kale u shaqeysaa sidii agonist-ka alpha7 nicotinic acetylcholine receptor (α7nAChR), kaas oo yareeya bararka neerfaha ee cudurka Alzheimers, waana mid gebi ahaanba la sameeyay. Wgx50 waxay muujisay natiijooyin dhiirigelin leh oo ku saabsan daraasadaha kahor-kiliinikada, oo ay ku jiraan joojinta apoptosis-ka neerfaha ee Aβ uu keeno, yaraynta sunta calcium-ka neerfaha, yaraynta ururinta oligomers-ka Aβ ee maskaxda, iyo hagaajinta waxqabadka garashada ee jiirka.
