Lemairamin (WGX-50) soo saaraha budada CAS No.: 29946-61-0 98.0% nadiifinta min. maaddooyinka dheeriga ah
Fiidiyowga Alaabta
Qiyaasta Alaabta
| Magaca alaabta | Lemairamin |
| Magac kale | 2-Propenamide, N- [2- (3,4-dimethoxyphenyl) ethyl] -3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| CAS Maya. | 29946-61-0 |
| qaacidada molecular | C19H21NO3 |
| Miisaanka molecular | 311.37 |
| daahirnimo | 98.0% |
| Muuqashada | Caddaan ilaa budo caddaan ah |
| Codsiga | Kaabista Cunnada Maaddada Ceyriinka ah |
hordhaca alaabta
Lemairamin ama Wgx50 waa iskudhis dabiici ah oo laga soo saaray basbaaska basbaaska taasoo muujisay natiijooyin rajo leh oo ka hortagga cudurka Alzheimers. Cilmi-baaristu waxay ogaatay in ay joojin karto Aβ-ku-soo-baxa neuronal apoptosis, waxay yaraynaysaa sunta kalsiyumka neuronal, waxayna yaraynaysaa ururinta Aβ oligomers ee kiliyaha maskaxda. Intaa waxaa dheer, wgx50 ayaa la tusay si ay u horumariso waxqabadka garashada ee jiirarka. Cilmi-baaristu waxay soo jeedinaysaa in wgx50 uu leeyahay awood uu kaga hortago isku-ururinta borotiinka-protein ee u dhexeeya molecules amyloid. Guud ahaan, wgx50 waxay leedahay karti ay uga hortagto cudurka Alzheimers waxaana laga yaabaa inay bixiso dariiqyo cusub oo loogu talagalay horumarinta daawooyinka lagu beegsanayo Aβ oligomers. Intaa waxaa dheer, WGX-50 waxay soo bandhigaysaa firfircoonida ka hortagga bararka, taas oo ka dhigaysa musharax rajo leh oo loogu talagalay daaweynta cudurrada bararka. WGX-50 ayaa la ogaaday inay saameyn weyn ku leedahay maqaarka, sida yareynta laalaabyada iyo hagaajinta barti maqaarka. Marka lagu daro xeryahooda dabiiciga ah ee laga soo saaro geedka Zanthoxylum bungeanum, waxaa hadda jira xeryahooda synthetic oo badan oo loo isticmaalo codsiyo kala duwan oo ku habboon suuqa.
Muuqaal
(1) Nadiifin sare: Lemairamin wuxuu ku heli karaa alaabo nadiif ah iyada oo loo marayo soo saarista dabiiciga ah iyo hagaajinta hababka wax soo saarka. Nadiifin sare waxay ka dhigan tahay helitaan noole oo wanaagsan iyo falcelin xun oo yar.
(2) Badbaadada: Badbaadada sare, falcelin xun oo yar, ma jiraan falcelin xun oo muuqda xitaa isticmaalka muddada dheer.
(3) Xasilloonida: Lemairamin waxay leedahay xasillooni wanaagsan waxayna sii wadi kartaa dhaqdhaqaaqeeda iyo saameynteeda deegaanno kala duwan iyo xaaladaha kaydinta.
(4) Way fududahay in la nuugo: Lemairamin si dhakhso ah ayuu u nuugi karaa jidhka bini'aadamka waxaana loo qaybin karaa unugyo iyo xubno kala duwan.
Codsiyada
Lemairamin waa iskudhis amide ah oo laga soo saaray jilif geedka Zanthoxylum bungeanum. Waqtigan xaadirka ah loo isticmaalo sida cunto dheeri ah, waxay sidoo kale u shaqeysaa sida agonist ee alpha7 nicotinic acetylcholine receptor (α7nAChR), kaas oo yareynaya neuroinflammation ee cudurka Alzheimers, oo si buuxda u synthetic.Wgx50 ayaa muujiyay natiijooyin dhiirigelin ah ee daraasadaha preclinical, oo ay ku jiraan in la joojiyo Aβ-induced neuronal neuronal. apoptosis, yaraynta sunta kalsiyumka neuronal, yaraynta ururinta Aβ oligomers ee kiliyaha maskaxda, iyo hagaajinta waxqabadka garashada ee jiirarka.
