CMS121 soo saaraha budada CAS No.: 1353224-53-9 98.0% nadiifinta min. maaddooyinka dheeriga ah
Qiyaasta Alaabta
| Magaca alaabta | CMS121 |
| Magac kale | CMS-121; 1,2-Benzenediol,4-[4- (cyclopentyloxy) -2-quinolinyl] -; 4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121); ACC, AcetylCoenzymeACarboxylase, cudur, neuroprotective, ka hortagga, anti-bararka, mitochondrial, Alzheimers, antioxidative, acetylation, Inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, waallida, ACC1, CMS-121 |
| CAS Maya. | 1353224-53-9 |
| qaacidada molecular | C20H19NO3 |
| Miisaanka molecular | 321.37 |
| daahirnimo | 98.0% |
| Muuqashada | budo huruud ah oo khafiif ah |
| Codsiga | Kaabista Cunnada Qalabka Ceyriinka ah |
hordhaca alaabta
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol waa xarun sidoo kale loo yaqaan CMS121. Kakanaanta dhisme ee xarunta ayaa soo jeedinaysa inay yeelan karto sifooyin gaar ah iyo isticmaalyo suurtagal ah. Si loo fahmo muhiimada ay leedahay, waxay kaa caawinaysaa in la aqoonsado kooxaha shaqaynaya ee jooga oo la falanqeeyo saamayntooda iman karta. Joogitaanka giraanta quinoline waxay soo jeedinaysaa in xaruntu ay noqon karto mid bayooloji ahaan firfircoon. Unugyada ka soo jeeda Quinoline waxaa lagu yaqaanaa sifooyin bayooloji oo kala duwan, oo ay ku jiraan hawlaha bakteeriyada iyo ka hortagga bararka. Lifaaqa kooxda cyclopentyloxy waxay gacan ka geysan kartaa milanka xarunta ama waxay kor u qaadi kartaa dhaqdhaqaaqeeda bayooloji iyada oo loo marayo saameyn aan fiicneyn. Daraasadaha ku saabsan unugyada HT22, CMS-121 waxay soo bandhigtay saameynaha neuroprotective ee muhiimka ah, si wax ku ool ah uga ilaalinta unugyadaas ischemia iyo waxyeelada oksida. Intaa waxaa dheer, CMS-121 waxay leedahay sifooyin muhiim ah oo ka hortagga bararka, taas oo muujinaysa awoodda ay u leedahay inay wax ka beddesho jawaabaha bararka. Marka sidaas la sameeyo, CMS-121 waxay awood u leedahay inay yareyso bararka unugyada iyo xubnaha kala duwan. CMS-121 waxay leedahay firfircooni dawooyin xoog leh oo ka hortag ah acetyl-CoA carboxylase 1 (ACC1). Saameynteeda xakamaynta xoogga leh ee ACC1 waxay ka dhigaysaa xarun rajo leh.
Muuqaal
(1) Nadiifin sare: CMS-121 waxay ku heli kartaa alaab saafi ah iyada oo loo marayo hababka wax soo saarka ee la safeeyey. Nadaafadda sare waxay ka dhigan tahay helitaan noole oo wanaagsan iyo falcelin xun oo yar.
(2) Badbaadada: Badbaadada sare, falcelin xun oo yar.
(3) Xasilloonida: CMS-121 waxay leedahay xasillooni wanaagsan waxayna sii wadi kartaa dhaqdhaqaaqeeda iyo saameynteeda hoos yimaada deegaan iyo xaalado kaydin oo kala duwan.
Codsiyada
CMS-121 waa soosaar quinolone ah iyo afka firfircoon acetyl-CoA carboxylase 1 (ACC1) inhibitor oo leh astaamo dawooyin ah oo rajo leh. Cilmi-baaris ballaaran ayaa la sameeyay si loo baaro faa'iidooyinka suurtagalka ah ee CMS-121 meelo kala duwan, oo ay ku jiraan neuroprotection, saameynta anti-bararka, dhaqdhaqaaqa antioxidant, iyo saameynta ay ku leedahay calaamadaha la xidhiidha gabowga caafimaadka qaba.
