NRC CAS No.: 23111-00-4 98.0% daahirnimo min.Anti-gabowga
Qiyaasta Alaabta
| Magaca alaabta | Nikotinamide Riboside Chloride |
| Magac kale | NicotinamideB-DRibosideChloride(WX900111); NicotinamideRiboside.Cl;Nicotimideribosidechloride; Pyridinium,3- (aminocarbonyl) -1-β-D-ribofuranosyl-, chloride (1: 1); 3-carbamoyl-1-(2R,3R,4S,5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-iumchloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridiniumchloride; 3-Carbamoyl-1-beta-D-ribofuranosylpyridiniumchloride |
| CAS Maya. | 23111-00-4 |
| qaacidada molecular | C11H15ClN2O5 |
| Miisaanka molecular | 290.7 |
| daahirnimo | 98.0% |
| Muuqashada | Caddaan ilaa budo caddaan ah |
| Codsiga | Kaabista Cunnada Qalabka Ceyriinka ah |
hordhaca alaabta
Nikotinamide Riboside Chloride waa biomolecule iyo ka-soo-saar fiitamiin B3 kaas oo la nuugi karo oo lagu dheefi karo jidhka bini'aadamka oo u noqda horudhac coenzyme NAD + (nicotinamide adenine dinucleotide).Coenzyme NAD + waxay ka ciyaartaa doorar badan oo muhiim ah jirka bini'aadamka, oo ay ku jiraan dheef-shiid kiimikaadka tamarta gacanta, hagaajinta DNA, iyo apoptosis unugga.
Saamaynta bayooloji ee Nicotinamide Riboside Chloride ayaa si weyn loo darsay.Waxay kor u qaadi kartaa shaqada mitochondrial, taas oo hagaajinaysa dheef-shiid kiimikaadka tamarta gacanta.Kordhinta dheef-shiid kiimikaadka tamarta ayaa laga yaabaa inay faa'iido u leedahay caafimaadka wadnaha, dulqaadka muruqa, iyo cilladaha dheef-shiid kiimikaadka.Intaa waxaa dheer, Nicotinamide Riboside Chloride ayaa la aaminsan yahay in ay kor u qaaddo hagaajinta DNA-da iyo apoptosis unug, taas oo ka caawinaysa ka hortagga dhacdooyinka kansarka iyo cudurrada kale.
Nikotinamide Riboside Chloride waxa kale oo ay wanaajin kartaa shaqada hab-dhiska difaaca ee bini’aadamka, isaga oo ka caawinaya iska caabinta caabuqyada fayraska iyo bakteeriyada.Daraasaduhu waxay muujiyeen in Nicotinamide Riboside Chloride ay kor u qaadi karto waxqabadka unugyada difaaca qaarkood, oo ay ku jiraan unugyada dilaaga dabiiciga ah iyo unugyada CD8+ T.Unugyadani waxay door muhiim ah ka ciyaaraan la dagaalanka caabuqa iyo burooyinka.
Guud ahaan, cilmi baarista Nicotinamide Riboside Chloride wali waxay ku jirtaa heerarkeedii hore waxaana loo baahan yahay daraasado caafimaad oo badan si loo caddeeyo waxtarkeeda iyo badbaadada.Si kastaba ha ahaatee, saameynteeda bayooloji ayaa si weyn loo baaray waxaana la rumeysan yahay inay leedahay faa'iidooyin caafimaad iyo daweyn oo badan oo suurtagal ah.
Muuqaal
(1) Hordhac NAD +: Nicotinamide Riboside Chloride waa horudhac nicotinamide adenine dinucleotide (NAD +), koenzyme ka ciyaara door muhiim ah habab badan oo bayooloji ah, oo ay ku jiraan dheef-shiid kiimikaad tamarta gacanta, hagaajinta DNA, iyo calaamadaynta unugyada.Iyadoo la siinayo isha NAD +, Nicotinamide Riboside Chloride ayaa laga yaabaa inay gacan ka geysato hagaajinta hababkan iyo kor u qaadida caafimaadka guud.
(2) Saamaynta gabowga: Nicotinamide Riboside Chloride ayaa la muujiyay in ay leedahay saameyn lid ku ah gabowga, gaar ahaan marka la eego shaqada mitochondrial.Daraasaduhu waxay soo jeedinayaan in kabitaannada Nicotinamide Riboside Chloride ay kordhin karto heerarka NAD + oo ay kor u qaaddo biogenesis-ka mitochondrial, taas oo laga yaabo inay ka caawiso la dagaallanka hoos u dhaca da'da ee shaqada gacanta.
(3) Saamaynta Neuroprotective: Nicotinamide Riboside Chloride ayaa sidoo kale lagu muujiyay inay leedahay saameyn neuroprotective, iyadoo cilmi-baarisyada qaar ay soo jeedinayaan inay gacan ka geysan karto hagaajinta shaqada garashada iyo ka hortagga cudurrada neerfaha sida Alzheimers iyo Parkinson.
(4) Waxyeelooyinka ugu yar: Nikotinamide Riboside Chloride waxaa la ogaaday in uu yahay mid badbaado leh oo si wanaagsan loo dulqaadan karo, iyada oo waxyeelo yar la soo sheegay.Waxa kale oo ay si dabiici ah uga dhacdaa cuntooyinka qaarkood, sida caanaha iyo khamiirka, taas oo sii xoojinaysa muuqaalkeeda badbaadada.
Codsiyada
Nikotinamide Riboside Chloride waa biomolecule si weyn loo bartay oo laga soo qaatay fitamiin B3 wuxuuna u adeegaa horudhac u ah koenzyme NAD + jirka, isagoo ciyaaraya door muhiim ah oo bayooloji ah.Waqtigan xaadirka ah, meelaha ugu muhiimsan ee codsiga ee Nicotinamide Riboside Chloride waxaa ka mid ah cudurrada wadnaha iyo xididdada dhiigga, cudurrada neurodegenerative, cudurrada dheef-shiid kiimikaadka, iyo gabowga ka hortagga.Tusaale ahaan, Nicotinamide Riboside Chloride waxay gacan ka geysan kartaa hagaajinta cudurrada la xiriira dheef-shiid kiimikaadka sida cudurrada wadnaha iyo xididdada dhiigga, sonkorowga, iyo buurnaanta iyadoo kordhinaysa dheef-shiid kiimikaadka tamarta gacanta iyo hagaajinta shaqada mitochondrial.Intaa waxaa dheer, Nikotinamide Riboside Chloride waxaa la rumeysan yahay inay leedahay awood lagula dagaallamo cudurrada neurodegenerative iyo ka hortagga gabowga.Daraasaduhu waxay muujiyeen in Nicotinamide Riboside Chloride ay hagaajin karto awoodda garashada iyo shaqada habdhiska dareenka ee jiirka waayeelka ah.
Intaa waxaa dheer, Nicotinamide Riboside Chloride ayaa loo isticmaalay in lagu daaweeyo cilladaha dheef-shiid kiimikaadka uracil, kaas oo ah cillad dheef-shiid kiimikaad ah oo naadir ah.
Maaddaama cilmi-baarista Nicotinamide Riboside Chloride ay sii waddo inay sii qotonto, rajada codsigeeda ayaa noqonaysa mid sii ballaaran.Tusaale ahaan, Nicotinamide Riboside Chloride waxaa loo isticmaali karaa kaansar dawo ahaan.Cilmi baaris ayaa muujisay in Nicotinamide Riboside Chloride ay kor u qaadi karto hagaajinta DNA-da iyo apoptosis-ka unugga, taas oo ka caawinaysa ka hortagga dhacdooyinka kansarka iyo cudurrada kale.Intaa waxaa dheer, Nicotinamide Riboside Chloride waxay wanaajin kartaa shaqada habka difaaca aadanaha, taasoo ka caawineysa iska caabinta caabuqyada fayraska iyo bakteeriyada.Codsiyadan suurtagalka ah ayaa ka dhigaya Nicotinamide Riboside Chloride mid ka mid ah meelaha ugu badan ee cilmi baarista.
Intaa waxaa dheer, habka isku dhafka kiimikada ee Nicotinamide Riboside Chloride ayaa si joogto ah u soo hagaagaya, qiimaha wax soo saarkeeduna wuu sii yaraanayaa, kaas oo sidoo kale bixiya fursado badan oo loogu talagalay codsigeeda caafimaadka.Sidaa darteed, Nicotinamide Riboside Chloride waxaa la filayaa inay noqoto biomolecule leh rajooyin ballaadhan mustaqbalka.
