Soo saaraha budada Agomelatine CAS No.: 138112-76-2 99% nadiifinta min.maaddooyinka dheeriga ah
Qiyaasta Alaabta
| Magaca alaabta | Agomelatine |
| Magac kale | N-[2- (7-Methoxy-1-naphthyl) ethyl] acetamide; N-[2- (7methoxynaphthalen-1-yl) ethyl] acetamide |
| CAS Maya. | 138112-76-2 |
| qaacidada molecular | C15H17NO2 |
| Miisaanka molecular | 243.3082 |
| daahirnimo | 99.0% |
| Muuqashada | budo cad |
| Baakad | 1kg/bac 25kg/drum |
| Codsiga | Alaabta cayriin ee caafimaadka |
hordhaca alaabta
Agomelatine waa nooc cusub oo ka hortagga niyad-jabka.Nidaamkeeda ficilku wuxuu jebiyaa nidaamka gudbiyaha monoamine ee dhaqanka.Waxay kicisaa reseptors melatonin, MT1 iyo MT2, waxayna ka soo horjeedaa 5-HT2C reseptors.Waxay hagaajin kartaa tayada hurdada waxayna dib u soo celin kartaa laxanka noolaha iyada oo leh saameyn liddi ku ah niyad-jabka;iyaga ka mid ah, iyada oo ka soo horjeeda soo-dhoweynta 5-HT2C ee xuubka postsynaptic, waxay kordhin kartaa sii-deynta DA iyo NE ee kiliyaha hore ee hore waxayna ciyaaraan door ka hortag ah.Marka MT agonism iyo 5-HT2C reseptor antagonism ay jiraan isla waqti isku mid ah, saameyn isku mid ah oo gaar ah ayaa la soo saari karaa si kor loogu qaado sii deynta DA iyo NE badan oo ku yaal aagga maskaxda ee PFC, taas oo sii xoojinaysa saameynta antidepressant.Intaa waxaa dheer, agomelatine waxay sidoo kale kor u qaadi kartaa sii deynta neurotrophic-ka-soo-baxa maskaxda ee PFC oo xannibaya sii-deynta walaaca ee glutamate ee gobolka maskaxda amygdala.
Muuqaal
(1) Nidaamyo laba-jibbaaran: Ma nidaamin karto oo keliya soo-deynta melatonin, laakiin sidoo kale waxay nidaamin kartaa sii-deynta 5-hydroxytryptamine iyo norepinephrine, sidaas darteed waxay door ka ciyaareysaa nidaaminta niyadda, hurdada, xanuunka iyo wixii la mid ah.
(2) Hagaajinta hurdada: Agomelatine waa ka wanaajin kara hurdo la'aanta iyada oo aan keenin hurdo ama miyir beel.
(3) Hagaajinta shaqada garashada: Agomelatine wuxuu wanaajin karaa shaqada garashada isagoo hagaajinaya neuroplasticity ee hippocampus.
(4) Badbaadada sare: Marka la barbar dhigo dawooyinka kale ee niyad-jabka, daawadu waxay leedahay saameyn yar marka la daweynayo niyad-jabka, mana saameyn doonto shaqada galmada iyo miisaanka jirka.
Codsiyada
Agomelatine waxaa loogu talagalay daawada niyad-jabka kaas oo sidoo kale ah melatonin antagonist.Waxay yaraynaysaa calaamadaha niyad-jabka iyadoo wax ka beddelaysa heerarka melatonin MT1 reseptors (si loo yareeyo calaamadaha alaarmiga kortikal) iyo MT2 reseptors (ilaa laxanka wareegga hurdada) iyo serotonin.Qaadashada habeenkii si loogu ekaado laxanka dabiiciga ah ee sii daynta melatonin, waxay si weyn u wanaajin kartaa tayada hurdada.
