5-Amino-1-methylquinolinium chloride Lambarka CAS:42464-96-0 98.0% daahirnimo ugu yaraan | soo saaraha maaddooyinka dheeraadka ah
Cabbiraadaha Badeecada
| Magaca alaabta | 5-Amino-1-methylquinolinium chloride(5-amino-1MQ) |
| Magac kale | 5-amino-1MQ5-Amino-1-mq koloriin 5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinolin-1-ium chloride 5-AMINO-1-METHYLQUINOLIN-1-IUM KLOEIDE 5-Amino-1-methyl-1-quinolinium chloride |
| Lambarka CAS. | 42464-96-0 |
| Qaacidada moolikaalka | C₁₀H₁₁ClN₂ |
| Miisaanka molecular-ka | 194.6 |
| Daahirnimo | 98% |
| Muuqaalka | Bunni ilaa bunni casaan ah oo adag |
| Baakad | 1kg/bac, 25kg/foosto |
| Codsiga | Qalabka Cuntada ee Cayriin ah |
Soo bandhigida badeecada
5-Amino-1-methylquinolinium chloride waa enzyme aad loo muujiyo inta lagu jiro gabowga muruqa lafaha waxaana lala xiriiriyaa hagaajinta dhaawaca marinnada NAD+, dhaqdhaqaaqa sirtuin1 ee aan nidaamsanayn, iyo kordhinta gabowga unugyada asliga ah ee muruqa. 5-Amino-1-methylquinolinium chloride waxay kor u qaadaa kala duwanaanshaha myoblast in vitro waxayna xoojisaa isku-darka iyo dib-u-cusboonaysiinta unugyada asliga ah ee muruqa ee jiirarka da'da ah. 5-Amino-1-methylquinolinium chloride sidoo kale waa joojiye xooggan oo nicotinamide N-methyltransferase (NNMT), iyadoo si xushmad leh ugu xidhan haraaga goobta isku xidhka substrate-ka NNMT. 5-Amino-1-methylquinolinium chloride waxay kor u qaadaa kala duwanaanshaha myoblast in vitro waxayna xoojisaa isku-darka iyo dib-u-cusboonaysiinta unugyada asliga ah ee muruqa ee jiirarka da'da ah. Kuwaas waxaa ka mid ah, enzyme-ka cytosolic nicotinamide N-methyltransferase (NNMT) ayaa dhawaan la ogaaday si loo xakameeyo heerarka horudhaca nicotinamide ee looga baahan yahay biosynthesis-ka NAD+, sidaas darteedna waxay door muhiim ah ka ciyaartaa nidaaminta marinnada badbaadinta NAD+ iyo dheef-shiid kiimikaadka unugyada.
5-Amino-1-Methylquinolinium Chloride waxay ka shaqeysaa microbiome-kaaga si ay u yareyso unugyada dufanka leh waxayna kaa caawineysaa inaad miisaankaaga lumiso. Marka unugyada dufanka badan ay ururaan, jirkaagu wuxuu si xad dhaaf ah u soo saaraa ensaym loo yaqaan NNMT (nicotinamide N-methyltransferase). Inta badan NNMT, jirkaagu wuxuu kordhiyaa bararka wuxuuna kaydiyaa dufanka. 5-Amino-1-Methylquinolinium Chloride wuxuu joojiyaa NNMT, taasoo u oggolaanaysa jirkaaga inuu hoos u dhigo miisaanka xad-dhaafka ah.
Muuqaalka
(1) Nadiifnimo sare: 5-Amino-1-methylquinolinium chloride waxay heli kartaa badeecooyin saafi ah iyada oo loo marayo hababka wax soo saarka ee la safeeyey. Nadiifnimo sare macnaheedu waa helitaan wanaagsan oo noolaha ah.
(2) Bartilmaameed: 5-Amino-1-methylquinolinium chloride si gaar ah ayuu u bartilmaameedsadaa ensaymka NNMT wuxuuna si wax ku ool ah u joojin karaa dhaqdhaqaaqiisa, taasoo saameyn ku yeelan karta habka dheef-shiid kiimikaadka ee nicotinamide.
(3) Xasillooni: 5-Amino-1-methylquinolinium chloride waxay leedahay xasillooni wanaagsan waxayna ilaalin kartaa firfircoonideeda iyo saameynteeda iyadoo la raacayo jawiyo iyo xaalado kaydin oo kala duwan.
(4) Rajooyinka horumarinta: Iyada oo ay ugu wacan tahay sifooyinka kala duwan ee 5-Amino-1-methylquinolinium chloride, horumarinteedu waxay heshay fiiro gaar ah waxayna leedahay cilmi-baaris ballaaran iyo rajooyin ku saabsan adeegsiga.
Codsiyada
5-Amino-1-methylquinolinium chloride waa nicotinamide N-methyltransferase (NNMT) oo joojisa kala-soocidda myoblast. 5-Amino-1-methylquinolinium chloride sidoo kale waxaa loo isticmaali karaa kaabis ahaan si loo yareeyo miisaanka iyo dufanka loona hagaajiyo dufanka beerka.
