5-Amino-1-methylquinolinium iodide(NNMTi) Lambarka CAS:42464-96-0 98.0% daahirnimo ugu yaraan | soo saaraha maaddooyinka dheeraadka ah
Cabbiraadaha Badeecada
| Magaca alaabta | 5-Amino-1-methylquinolinium iodide(NNMTi) |
| Magac kale | NNMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; iodide 5-Amino-1-methyl-1-quinolinium Iodide 5-Amino-1-mq iodide |
| Lambarka CAS. | 42464-96-0 |
| Qaacidada moolikaalka | C10H11IN2 |
| Miisaanka molecular-ka | 286.11 |
| Daahirnimo | 98.0% |
| Muuqaalka | Bunni ilaa bunni casaan ah oo adag |
| Baakad | 1kg/bac, 25kg/foosto |
| Codsiga | Qalabka Cuntada ee Cayriin ah |
Soo bandhigida badeecada
Ensaymka cytosolic nicotinamide N-methyltransferase (NNMT) ayaa dhawaan la ogaaday inuu nidaamiyo heerarka horudhaca nicotinamide ee looga baahan yahay biosynthesis-ka NAD+ sidaas darteedna wuxuu door muhiim ah ka ciyaaraa nidaaminta marinnada badbaadinta NAD+ iyo dheef-shiid kiimikaadka unugyada. NNMT waxaa lagu muujiyaa muruqa lafaha, muuqaalkiisuna si tartiib tartiib ah ayuu u kordhaa marka unugyada muruqa ay gaboobaan. Waxaa muhiim ah, NNMT waa qayb weyn oo ka mid ah saxiixa muujinta hidda-wadaha sarcopenic, muujinta xad-dhaafka ahna waxay horseedi kartaa hoos u dhac weyn oo ku yimaada heerarka NAD+ iyo hoos u dhaca cufka muruqa, xoogga, iyo shaqada la socota gabowga. Daaweynta jiirka da'da ah oo leh molecule yar oo NNMT inhibitor ah (NNMTi) waxay xoojisay awoodda faafitaanka, isku-darka, iyo dib-u-soo-nooleynta ee muSCs, taasoo hagaajinaysa waxqabadka shaqada ee muruqa lafaha. Natiijooyin la mid ah ayaa laga helay vitro iyadoo la adeegsanayo unugyada C2C12, kuwaas oo aad ugu eg muSCs, halkaas oo daaweynta NNMTi ay kor u qaadday kala-soocidda myoblast waxayna taageertay isbeddellada dheef-shiid kiimikaadka ee metabolites-ka unugyada ee la xiriira marinnada badbaadinta NAD +.
NNMTi waa ensaym aad u sarreeya oo la muujiyo inta lagu jiro gabowga muruqyada qalfoofka waxaana lala xiriiriyaa dhaawaca marinka NAD+, dhaqdhaqaaqa sirtuin1 ee aan nidaamsanayn, iyo kordhinta gabowga unugyada asliga ah ee muruqyada. NNMT waa ensaym dheef-shiid kiimikaad ah oo kiciya methylation-ka nicotinamide (NAM) iyadoo la adeegsanayo deeq-bixiyaha methyl-ka ee caalamiga ah S-adenosylmethionine (SAM), isagoo isku xiraya xaaladda dheef-shiid kiimikaadka ee unugyada dheelitirka methylation-ka iyo heerarka unugyada NAD+ ee gudaha. NNMT waxaa si weyn loogu muujiyaa beerka iyo unugyada adipose, iyo sidoo kale xaaladaha cudur-sidaha ee lagu garto baahida dheef-shiid kiimikaadka oo kordhay, sida cudurrada beerka dufanka leh qaarkood iyo macaanka. NNMT waxay ku lug leedahay habab kala duwan oo kala duwan, oo ay ku jiraan kala-guurka unugyada asliga ah ee embriyaha aadanaha ee aan caadiga ahayn ilaa kuwa bislaaday, myogenesis, iyo kala-guurka epithelial iyo neuromesenchymal ee kansarrada kala duwan. Muujinta NNMT waxaa lagu nidaamiyaa qaab unug iyo macne gaar ah halkii laga isticmaali lahaa qaab nidaamsan oo meel walba yaal.
Muuqaalka
(1) Nadiifnimo sare: NNMTi waxay heli kartaa badeecooyin saafi ah iyada oo loo marayo hababka wax soo saarka ee la safeeyey. Nadiifnimo sare macnaheedu waa helitaan wanaagsan oo noolaha ah.
(2) Bartilmaameed: NNMTi waxay si gaar ah u bartilmaameedsataa ensaymka NNMT waxayna si wax ku ool ah u joojin kartaa dhaqdhaqaaqeeda, taasoo saameyn ku yeelan karta habka dheef-shiid kiimikaadka ee nicotinamide.
(3) Xasillooni: NNMTi waxay leedahay xasillooni wanaagsan waxayna ilaalin kartaa dhaqdhaqaaqeeda iyo saameynteeda iyadoo la raacayo jawiyo iyo xaalado kaydin oo kala duwan.
(4) Rajooyinka horumarinta: Iyada oo ay ugu wacan tahay sifooyinka kala duwan ee NNMTi, horumarkeedu wuxuu helay fiiro gaar ah wuxuuna leeyahay cilmi-baaris ballaaran iyo rajooyin ku saabsan hirgelinta.
Codsiyada
NNMT (CAS 42464-96-0) waa nicotinamide N-methyltransferase (NNMT) inhibitor, oo ah joojiye awood leh (IC50=1.2 μM) oo ah nicotinamide N-methyltransferase (NNMT) kaas oo kor u qaada kala duwanaanshaha myoblast. NNMT waxay si xushmad leh ugu xidhaa haraaga goobta isku xidhka substrate-ka NNMT. NNMT waxay kor u qaadaa kala duwanaanshaha myoblast-ka in vitro waxayna kor u qaadaa isku-darka unugyada asliga ah ee muruqa iyo dib-u-cusboonaysiinta jiirarka da'da ah. NNMT waa enzyme biotransformation cytosolic aasaasi ah oo kiciya N-methylation ee xenobiotics-ka endogenous iyo exogenous. Marka la barbardhigo beddelka cuntada caatada ah oo keliya, daaweynta NNMT oo lagu daray beddelka cuntada caatada ah waxay dardar gelisaa horumarinta dufanka jirka oo yaraada, kordhinta cufnaanta jidhka oo dhan ilaa saamiga miisaanka jidhka, hoos u dhaca miisaanka unugyada adipose cad ee beerka epididymal, hoos u dhaca kaydka dufanka beerka, iyo hagaajinta steatosis-ka beerka. Intaa waxaa dheer, NNMT waxay kordhin kartaa xoogga waxayna kor u qaadi kartaa awoodda dib-u-soo-nooleynta ee muruqa da'da ah, taas oo faa'iido u yeelan karta daaweynta sarcopenia.
