Waa maxay N-Boc-O-Benzyl-D-Serine iyo maxay muhiim u tahay?

Warshadaha kiimikaadka iyo dawooyinka, N-Boc-O-benzyl-D-serine waa soosaar muhiim ah oo amino acid ah sababtoo ah isticmaalkeeda isku dhafka molecules bioactive iyo daawooyinka. Waxay soo jiidatay dareen badan oo loogu talagalay codsigeeda ballaaran ee horumarinta." N-Boc" waxaa loola jeedaa kooxda ilaalinta tert-butoxycarbonyl (Boc), taas oo inta badan loo isticmaalo si loo ilaaliyo kooxda amino ee acids amino ee isku-dhafka peptide. "O-Benzyl" macnaheedu waa in kooxda benzyl ay ku xiran tahay kooxda hydroxyl ee serine, taas oo kor u qaadeysa xasilloonida iyo milanka.

Hordhac N-Boc-O-benzyl-D-serine

N-Boc-O-benzyl-D-serine (CAS:47173-80-8), waxay u muuqataa sida budo cad ama cad, N-Boc-O-Benzyl-D-serine waa nooc ka mid ah amino acid D-serine. Iyada oo ay ugu wacan tahay sifooyinkeeda qaab-dhismeedka gaarka ah, waxa ay door muhiim ah ka ciyaartaa isku-dhafka kiimikaad iyo kimistariga peptide. Kuwan soo socda waa sharaxaad faahfaahsan oo ku saabsan qaybaheeda: halka N-Boc loola jeedo tert-butoxycarbonyl (Boc) kooxda ilaalinta.

Kooxaha ilaalinta waxaa loo isticmaalaa isku-dhafka dabiiciga ah si ay si ku-meel-gaar ah u difaacaan kooxaha shaqeynaya, iyagoo u oggolaanaya fal-celinnada xulashada iyada oo aan faragelin laga helin goobaha kale ee falcelinta. O-benzyl waxay muujinaysaa in kooxda benzyl ay ku dheggan yihiin ogsijiinta kooxda hydroxyl ee serine. Benzyl waa beddelka udgoonka caadiga ah kaas oo saameyn kara milanka iyo falcelinta isku-dhisyada. D-serine waa mid ka mid ah labada enantiomers ee serine waxaana iska leh qoyska methionine. Serine waa amino acid muhiim u ah biosynthesis, wax soo saarka tamarta iyo wax soo saarka wakiilka yaraynta intracellular. Nidaamyadani waxay muhiim u yihiin korriinka iyo badinta unugyada kansarka.

Hordhac N-Boc-O-benzyl-D-serine Function

1. D-serine waxay yarayn kartaa calaamadaha hoos u dhaca garashada.

Calaamadaha Glutaminergic waxaa loo yaqaanaa inay wanaajiso samaynta xusuusta sababtoo ah firfircoonida soo-dhoweynta NMDA waxay sababtaa qulqulka kaalshiyamka iyo abaabulida kinase-ku-tiirsanaanta calmodulin (CaMK) iyo borotiinnada CREB-ku-xidha, kuwaas oo u dhaqma inay kiciyaan awoodda muddada-dheer (LTP), taas oo aasaas u ah Farsamaynta loo yaqaan xusuusta, waxayna keentaa korodhka calaamadaynta NMDA (gaar ahaan iyada oo loo marayo qaybta NR2B) taasoo keenta korodhka xusuusta iyo LTP. Tani sidoo kale waa habka kobcinta xusuusta ee lagu arkay magnesium L-threonate. Sababtoo ah D-serine waxay kor u qaadi kartaa calaamadaynta iyada oo loo marayo soo-dhoweynta NMDA, oo lagu lammaaniyo waxqabadka D-serine ee habkan iyo dareenka la yaqaan ee unugyada hippocampal ee kicinta D-serine, waxaa la rumeysan yahay in kabidda D-serine ay kor u qaadi karto xusuusta iyo barashada.

2.Cilmi-baaristu waxay ogaatay in luminta borotiinka Menin ee hypothalamus ay tahay arrin muhiim ah oo horseedaysa gabowga, iyo kabidda D-serine waxay hagaajin kartaa naafonimada garashada ee jiirarka waayeelka ah.

Daraasaduhu waxay ogaadeen in hypothalamus ay sidoo kale door muhiim ah ka ciyaarto daciifnimada garashada ee ay keento gabowga. Inta lagu jiro habka gabowga, borotiinka Menin ee ku jira hypothalamus (hadda dambe loo yaqaan Menin) ayaa si tartiib tartiib ah u yaraan doona habka gabowga, saameynaya isku-darka D-serine, sii kordhinta habka gabowga iyo garashada garashada. Intaa waxaa dheer, kaabista D-serine waxay si weyn u wanaajin kartaa phenotype gabowga waxayna yareyn kartaa garashada garashada ee jiirarka da'da ah.

Natiijooyinka daraasadda ayaa muujisay in ka dib markii la kordhiyo D-serine, heerarka D-serine ee hypothalamus iyo hippocampus ee saddexda kooxood ee jiirarka ayaa si weyn u kordhay marka la barbar dhigo nooc isku mid ah oo aan lagu kabin D-serine (p) <0.01), iyo heerkooda garashada waa la hagaajiyay. Horumar la taaban karo (p<0.05), oo tilmaamaya in D-serine supplements ay noqon karto ikhtiyaar daawaynta hagaajinta naafanimada garashada ee la xiriirta gabowga.

N-Boc-O-Benzyl-D-Serine vs. Amino Acids kale: Waa maxay faraqa u dhexeeya?

1. Kala duwanaanshaha qaabdhismeedka

Farqiga ugu cad ee u dhexeeya N-Boc-O-benzyl-D-serine iyo asiidhyada amino-yada kale waa qaab-dhismeedkeeda. Iyadoo asiidhyada amino-yada caadiga ah ay leeyihiin laf-dhabar fudud oo ka kooban kooxaha amino, kooxaha karboksylka iyo silsiladaha dhinaca, N-Boc-O-benzyl-D-serine waxay leedahay kooxo firfircoon oo dheeraad ah oo beddela hantidooda.

Tusaale ahaan, kooxda Boc waxay bixisaa difaac inta lagu jiro isku-darka peptide, taas oo u oggolaanaysa fal-celin aad u adag in la sameeyo iyada oo aan la rabin falcelin dhinac ah. Kooxaha Benzyl waxay xoojiyaan isdhexgalka hydrophobic, taas oo saameynaysa laalaabida iyo xasilloonida peptides iyo borotiinnada.

2. Tilmaamaha shaqada

N-Boc-O-Benzyl-D-Serine waxay soo bandhigtaa sifooyin shaqo oo gaar ah marka loo eego asiidhyada amino-ga kale. Qaabaynteeda D waxay u ogolaataa inay si ka duwan ula falgasho hababka noolaha marka la barbar dhigo qaabaynta L ee caadiga ah ee laga helo borotiinnada intooda badan. Tani waxay u horseedi kartaa isbeddel ku yimaada dhaqdhaqaaqa noolaha, taasoo ka dhigaysa qalab qiimo leh oo naqshadeynta iyo horumarinta daroogada.

Taas bedelkeeda, ka fudud, asiidhyada amino-ka caadiga ah sida glycine ama alanine ma laha heer isku mid ah kakanaanta ama gaar ahaaneed ee isdhexgalka. Tani waxay ka dhigaysaa N-Boc-O-Benzyl-D-Serine si gaar ah faa'iido u leh daraasadaha neuropharmacology iyo isdhexgalka soo-dhoweynta.

3. Codsiyada cilmi baarista iyo daawada

N-Boc-O-Benzyl-D-Serine waxay soo jiidatay dareenka dhinacyo kala duwan, gaar ahaan dhinacyada kimistariga daawada iyo neerfaha. Awooddeeda lagu beddelo dhaqdhaqaaqa soo-dhowaynta NMDA waxay ka dhigaysaa musharraxa daroogada lagu barto xanuunnada neerfaha sida schizophrenia iyo cudurka Alzheimers. Cilmi-baadhayaashu waxay sahamiyaan kartideeda sida wakiilka daaweynta si kor loogu qaado shaqada garashada ama la yareeyo hababka neurodegenerative.

Taas bedelkeeda, asiidhyada amino-yada caadiga ah sida leucine ama valine ayaa inta badan lagu bartay doorka ay ku leeyihiin dheef-shiid kiimikaadka muruqa iyo isku-darka borotiinka. In kasta oo ay lagama maarmaan u yihiin guud ahaan caafimaadka iyo fayoobaanta, codsiyadooda la beegsaday ee neuropharmacology way ka duwan yihiin N-Boc-O-Benzyl-D-Serine.

4. Qalabaynta iyo Xasiloonida

Isku-dubaridka N-Boc-O-benzyl-D-serine waxay ku lug leedahay fal-celin kiimikaad oo ka adag marka loo eego amino acids-ka caadiga ah. Soo bandhigida kooxaha ilaalinta iyo baahida loo qabo xaalado gaar ah oo falcelin ah ayaa ka dhigi kara isku-duubnidooda mid aad u adag. Si kastaba ha ahaatee, isbeddelladani waxay sidoo kale kor u qaadaan xasilloonida, taas oo ka dhigaysa mid ku habboon xaalado kala duwan oo tijaabo ah.

Taas bedelkeeda, asiidhyada amino-yada caadiga ah guud ahaan diyaar bay u yihiin oo way fududahay in la soo saaro, laakiin waxaa laga yaabaa inaanay bixin isla heerka xasilloonida ama gaarnimada looga baahan yahay codsiyada cilmi-baadhiseed ee horumarsan.

Codsiyada D-Real-Life ee N-Boc-O-Benzyl-D-Serine

Serine waxay ka ciyaartaa hawlaha nafsiga ah ee muhiimka ah ee jidhka bini'aadamka, gaar ahaan nidaaminta iyo ilaalinta habdhiska dareenka. N-Boc-O-benzyl-D-serine sida derivative serine waa qayb muhiim ah oo ka mid ah molecules bioactive kaas oo inta badan loo isticmaalo isku dhafka peptide iyo codsiyada kale ee kimistariga organic, gaar ahaan horumarinta daawooyinka iyo xeryahooda bioactive. Kooxda ilaalinta waxa lagu saari karaa shuruudo gaar ah si loo helo asiidhyada amino-yada ee bilaashka ah ama waxyaabaha kale ee ka soo baxa si loo helo cilmi baadhis dheeraad ah ama codsi. Si weyn loogu isticmaalo cilmi-baarista caafimaadka iyo bayoolajiga.

1. Isku-dhafka kiimikaad iyo kiimiko peptide

N-Boc-O-benzyl-D-serine waxaa loo isticmaalaa sidii dhisme dhisme ah oo ka mid ah isku dhafka kiimikada ee xeryahooda kala duwan iyo sidoo kale qayb muhiim ah oo ka mid ah kiimikada peptide. Isticmaalkeeda goobtan waxaa sabab u ah awoodda ay u leedahay in lagu daro qaababka molecular ee waaweyn, caawinta horumarinta dawooyinka cusub iyo molecules bioactive.

2. Warshadaha dawooyinka

N-Boc-O-benzyl-D-serine waxaa loo adeegsaday horudhac u ah diyaarinta naphthodiazolidinones la beddelay. Xeryahooda waxay u dhaqmaan sida borotiinka tyrosine phosphatase degraders waxayna leeyihiin codsiyo daweyn oo suurtagal ah ee daaweynta kansarka iyo cudurrada dheef-shiid kiimikaadka. Hoos-u-dhac ku yimaadda phosphatases-kan waxay gacan ka geysataa nidaaminta waddooyinka calaamadaynta unugyada, taas oo bixisa hab daaweyn ah oo lagula dagaallamo cudurradan.

3. Cilmi-baarista iyo horumarinta

Cilmi baarista iyo horumarinta, N-Boc-O-benzyl-D-serine waxaa loo isticmaalaa in lagu soo saaro unugyo cusub oo leh firfircooni bayooloji ah. Qaab dhismeedkeeda gaarka ah ayaa u oggolaanaya saynisyahannada inay sahamiyaan hantidooda iyo codsiyadooda si ay u abuuraan dawooyin cusub iyo daawayn xaalado caafimaad oo kala duwan.

Halkee laga iibsan karaa N-Boc-O-benzyl-D-serine?

Sida soo saaraha N-Boc-O-benzyl-D-serine budada, Suzhou Myland waxay ku guulaysatay kalsoonida macaamiil badan oo leh alaabteeda nadiifka ah iyo xakamaynta tayada adag. Shirkadda waxaa ka go'an in ay macaamiisha siiso agab cayriin oo tayo sare leh iyo ka caawinta in ay ku guulaystaan ​​warshadahooda.

1. Tayada alaabta lagu kalsoonaan karo

Suzhou Myland's N-Boc-O-benzyl-D-serine budada waxay martaa baaritaanno badan si loo hubiyo in nadiifnimadeeda iyo tayada ay la kulmaan heerarka warshadaha. Shirkaddu waxay leedahay koox kormeer tayo leh oo xirfad leh oo si joogto ah u kormeerta badeecooyinka si loo hubiyo tayada xasilloon ee qayb kasta oo alaab ah.

2. Awoodaha sahayda ee dabacsan

Haddi ay tahay dufcad yar ama habab baaxad leh, Suzhou Mailun Biotechnology waxa ay uga jawaabi kartaa dabacsanaan si loo hubiyo in baahiyaha macaamiisha la daboolo. Shirkaddu waxay samaysay nidaam saadka oo dhammaystiran si ay si dhakhso leh ugu gaarsiiso macaamiisha.

3. Taageero farsamo xirfadeed

Kooxda R&D ee Suzhou Myland waxay ka kooban tahay tiro khubaro dhinaca warshadaha ah waxayna siin karaan macaamiisha la tashi farsamo iyo taageero si ay macaamiisha uga caawiyaan inay si fiican u fahmaan oo ay u dabaqaan N-Boc-O-benzyl-D-serine.

4. Qiimaha tartanka

Marka la eego dhismaha hubinta tayada badeecada, Suzhou Myland waxay bixisaa qiimayaal tartan ah si ay uga caawiso macaamiisha inay dhimaan kharashaadka wax iibsiga iyo horumarinta tartanka suuqa.

Doorashada alaab-qeybiyaha saxda ah ee N-Boc-O-benzyl-D-serine waa furaha hubinta tayada iyo badbaadada alaabta. Suzhou Myland waxay noqotay doorasho lagu kalsoonaan karo ee warshadaha leh alaabteeda nadiifka ah, xakamaynta tayada adag iyo adeegyada xirfadeed. Haddii aad tahay shirkad dawooyin ah ama machad cilmi-baaris cilmiyeed, Suzhou Myland waxay ku siin kartaa budada N-Boc-O-benzyl-D-serine tayo sare leh si ay u caawiso cilmi-baaristaada iyo horumarkaaga. Faahfaahin dheeraad ah, fadlan booqo bogga rasmiga ah ee Suzhou Myland.