Waa maxay spermidine? Tilmaamaha fudud ee spermidine

Shaybaarkawaa nooc ka mid ah polyamine. Polyamines waa biomolecules yaryar, dufan leh, polycationic (-NH3+). Waxaa jira afar polyamines oo ugu muhiimsan naasleyda: spermine, spermidine, putrescine iyo cadaverine. Spermine wuxuu ka tirsan yahay tetramines, spermidine wuxuu ka tirsan yahay triamines, putrescine iyo cadaverine waxay ka tirsan yihiin diamines. Tiro kala duwan oo kooxaha amino ah ayaa siiya sifooyin kala duwan oo jireed.

Shaybaarka aadanaha

Spermidine kuma jiro oo keliya shahwada, laakiin sidoo kale si weyn ayuu ugu fidaa unugyada kale iyo unugyada jidhka bini'aadamka. Xoogga spermidine-ka ee unugyada gudaha ku jira wuxuu inta badan ku xiran yahay afar arrimood:

① Sameynta unugyada gudaha:

Arginine → putrescine → spermidine ← spermine. Arginine waa walaxda ugu weyn ee cayriin ee loogu talagalay isku-darka spermidine ee unugyada. Waxaa kiciya arginase si loo soo saaro ornithine iyo urea. Ornithine waxaa markaa loo isticmaalaa in lagu soo saaro putrescine iyadoo la adeegsanayo ornithine decarboxylase (ODC1). Tani waa tallaabada xaddidaysa heerka), putrescine wuxuu soo saaraa spermidine iyadoo la adeegsanayo spermidine synthase (SPDS). Spermidine waxaa sidoo kale soo saari kara burburka spermidine.

②Qaadashada ka baxsan unugyada:

Waxaa loo qaybiyaa qaadashada cuntada iyo isku-darka microbial-ka xiidmaha. Cuntooyinka hodanka ku ah spermidine waxaa ka mid ah jeermiska qamadiga, natto, soybeans, boqoshaada, iwm. Spermine iyo spermidine-ka laga liqo cuntada si dhakhso ah ayaa looga nuugaa mindhicirrada waxaana loo qaybiyaa iyada oo aan la burburin, sidaa darteed isku-darka spermidine-ka ee dhiigga ku jira waa Isku-darka aad ayuu u kala duwan yahay. Bakteeriyada probiotic-ka ee ku jirta microbiota mindhicirka sida Bifidobacterium ayaa sidoo kale samayn karta spermidine.

③Katabolism:

Shaybaarka ku jira jirka ayaa si tartiib tartiib ah ugu burbura spermidine iyo putrescine iyadoo loo marayo N1-acetyltransferase (SSAT), polyamine oxidase (PAO) iyo amine oxidase kale, halka putrescine loo beddelo aminobutyric acid iyadoo la adeegsanayo oxidases. Ugu dambeyntii, amine ions iyo carbon dioxide ayaa laga soo saaraa oo laga soo saaraa jirka.

④Da'da:

Fiirsashada shahwada ayaa isbeddesha marka da'da la gaaro. Cilmi-baarayaashu waxay cabbireen fiirsashada polyamines-ka ee unugyada iyo xubnaha kala duwan ee jiirarka 3-toddobaadlaha ah, 10-toddobaadlaha ah iyo 26-toddobaadlaha ah waxayna ogaadeen in asal ahaan lagu hayo ganaca, maskaxda iyo ilmo-galeenka. Isbeddellada ku yimaada xiidmaha ayaa si yar hoos ugu dhaca marka da'da la gaaro, waxayna si weyn hoos ugu dhacaan thymus-ka, beeryarada, ugxan-sidaha, beerka, caloosha, sambabada, kelyaha, wadnaha iyo murqaha. Ma aha wax adag in aan qiyaasno in sababaha isbeddelkan ay ka mid yihiin isbeddellada cuntada, isbeddellada qaab-dhismeedka dhirta xiidmaha, hoos u dhaca dhaqdhaqaaqa polyamine synthase, iwm.

Bartilmaameed dabiici ah oo shahwada spermidine ah

Maxay molecule-ka yar ee fudud u yahay walax muhiim u ah jidhka bini'aadamka? Sirtu dhab ahaantii waxay ku jirtaa qaab-dhismeedkeeda: Spermidine waa molecule yar oo dufan leh oo polycationic (-NH3+) kaas oo ku jira qaab badan oo protonated ah xaaladaha pH-ga ee jirka, iyadoo ion-yada togan ay ku baahsan yihiin silsiladda kaarboonka. Dakhli koronto, wuxuu leeyahay firfircooni jireed oo xooggan.

Sidaa darteed, ha ahaato asiidhyada nucleic-ga, fosfolipids-ka, borotiinnada aashitada leh ee ka kooban haraaga aashitada, polysaccharides-ka pectic-ga oo ka kooban kooxaha carboxyl iyo sulfates, ama neerfayaasha neerfaha iyo hoormoonnada (dopamine, epinephrine, serotonin, hoormoonka thyroid, iwm.) oo leh qaab-dhismeedyo isku mid ah, Waxaa suurtogal ah in bartilmaameed laga dhigo isku xidhka spermidine-ka. Kuwa ugu muhiimsan waa:

① Asiidh nukliyeer ah:

Daraasaduhu waxay ogaadeen in inta badan polyamine-yadu ay ku jiraan qaab isku-dhafan polyamine-RNA ah oo ku jira unugyada, iyadoo 1-4 u dhigma polyamine ay ku xiran yihiin 100 u dhigma oo isku-dhafan oo fosfate ah. Sidaa darteed, doorka ugu weyn ee spermidine wuxuu la xiriiraa isbeddellada qaab-dhismeedka iyo turjumaadda RNA, sida saameynta marxaladaha kala duwan ee isku-darka borotiinka iyadoo saameynaysa qaab-dhismeedka labaad ee mRNA, tRNA iyo rRNA. Spermidine waxay sidoo kale samayn kartaa "buundooyin" deggan oo u dhexeeya xargaha DNA-da laba-helical, iyadoo yareyneysa helitaanka xagjirrada xorta ah ama wakiilada kale ee wax u dhimaya DNA-da, iyo ilaalinta DNA-da ka timaadda luminta kulaylka iyo shucaaca X-ray.

②Borotiin:

Spermidine waxay ku xidhmi kartaa borotiinnada sita dallacaadyo badan oo taban waxayna beddeli kartaa qaab-dhismeedka booska ee borotiinka, taasoo saameynaysa shaqadiisa jireed. Tusaalooyinka waxaa ka mid ah kinases-ka borotiinka/phosphatases (isku xidh muhiim ah oo ku jira marinno badan oo calaamadaha lagu beddelo), ensaymada ku lug leh methylation-ka histone iyo acetylation (saameynaya muujinta hidda-wadaha iyadoo la beddelayo epigenetics), acetylcholinesterase (qayb muhiim ah oo ka mid ah cudurrada neerfaha). mid ka mid ah daawooyinka daaweynta), soo-dhoweeyayaasha kanaalka ion (sida AMPA, soo-dhoweeyayaasha AMDA), iwm.

Suzhou Myland waa soo-saare ka diiwaan gashan FDA oo bixiya budada Spermidine tayo sare leh oo saafi ah.

Suzhou Myland, waxaan ka go'an nahay inaan bixinno alaabada tayada ugu fiican qiimaha ugu fiican. Budadayada Spermidine si adag ayaa loo tijaabiyaa si loo helo daahirnimo iyo awood, taasoo hubinaysa inaad hesho kaabis tayo sare leh oo aad ku kalsoonaan karto. Hadday tahay inaad taageerto caafimaadka unugyada, kor u qaadida difaaca jirkaaga ama kor u qaadida caafimaadka guud, budada Spermidine-ka ayaa ah doorashada ugu habboon.

Iyada oo leh 30 sano oo waayo-aragnimo ah oo ay hoggaaminayso tiknoolajiyad sare iyo istaraatiijiyad cilmi-baaris iyo horumarin oo aad loo habeeyay, Spermidine waxay samaysay noocyo kala duwan oo alaab tartan ah si ay u noqoto shirkad kaabis cilmi-baaris nololeed oo cusub, isku-darka gaarka ah iyo adeegyada wax soo saarka.

Intaa waxaa dheer, Suzhou Myland sidoo kale waa soo-saare ka diiwaangashan FDA. Kheyraadka cilmi-baarista iyo horumarinta ee shirkaddu, xarumaha wax soo saarka, iyo qalabka falanqaynta waa kuwo casri ah oo shaqeynaya badan, waxayna awood u leeyihiin inay soo saaraan kiimikooyin laga bilaabo milligram ilaa tan oo cabbir ah, waxayna u hoggaansamaan heerarka ISO 9001 iyo tilmaamaha wax soo saarka GMP.