Waa maxay shahwada? Hagaha fudud ee shahwada

spermidinewaa nooc ka mid ah polyamine. Polyamines waa yaryar, dufan, polycationic (-NH3+) biomolecules. Waxaa jira afar polyamines oo waaweyn oo ku jira naasleyda: shahwada, shahwada, putrescine iyo cadaverine. Xawada waxaa iska leh tetramines, shahwada waxaa iska leh triamines, putrescine iyo cadaverine waxaa iska leh diamines. Tirooyinka kala duwan ee kooxaha amino-yada ayaa siinaya astaamo jidheed oo kala duwan.

Spermidine ee dadka

Spermidine kaliya kuma jiraan shahwada, laakiin sidoo kale waxay si weyn ugu qaybsantaa unugyada kale iyo unugyada jidhka bini'aadamka. Isku-duubnaanta spermidine intracellular waxay inta badan ku xiran tahay afar arrimood:

①U-samaynta unugyadu:

Arginine → putrescine → spermidine ← shahwada. Arginine waa sheyga ugu muhiimsan ee isku dhafka spermidine ee unugyada. Waxaa loo yaqaan 'arginase' si ay u abuurto ornithine iyo urea. Ornithine ayaa markaa loo isticmaalaa in lagu soo saaro putrescine hoos yimaada ficilka ornithine decarboxylase (ODC1). Tani waa tillaabada xadaynta, putrescine waxay soo saartaa shahwada shahwada oo hoos timaada falgalka spermidine synthase (SPDS). Spermidine sidoo kale waxaa lagu soo saari karaa hoos u dhaca shahwada.

② Qaadashada unugyada dheeraadka ah:

U qaybsan qaadashada cuntada iyo isku-dhafka microbial xiidmaha. Cuntooyinka qani ku ah shahwada waxaa ka mid ah jeermiska qamadiga, natto, soybeans, boqoshaada, iwm. shahwada iyo shahwada laga soo dhex shubo cuntada ayaa si degdeg ah mindhicirka uga soo nuugo waxaana loo qaybiyaa iyada oo aan hoos u dhicin. Bakteeriyada Probiotic ee ku jirta microbiota mindhicirka sida Bifidobacterium waxay sidoo kale soo saari kartaa spermidine.

③Catabolism:

Shahwada jidhka ku jirta ayaa si tartiib tartiib ah u kala go'a shahwada iyo putrescine ee N1-acetyltransferase (SSAT), polyamine oxidase (PAO) iyo amine oxidases kale, halka putrescine ay sii badasho aminobutyric acid by oxidases. Ugu dambayntii, ion amine iyo kaarboon laba ogsaydh ayaa la soo saaraa oo laga soo saaraa jidhka.

④Da'da:

Isku-duubnaanta spermidine waxay isbeddelaysaa da'da. Cilmi-baarayaashu waxay qiyaaseen xoogga polyamines ee unugyo kala duwan iyo xubnaha 3-usbuuc, 10-usbuuc jira iyo 26-usbuuc jiirarka waxayna ogaadeen in asal ahaan lagu hayo beeryarada, maskaxda iyo ilmo-galeenka. Isbeddellada mindhicirku wax yar ayuu hoos u dhacaa marka ay da'da gaadhaan, si weynna hoos ugu dhacaan thymus, beeryarada, ugxan-sidaha, beerka, caloosha, sambabada, kelyaha, wadnaha iyo muruqa. Ma aha wax nagu adag inaan qiyaasno in sababaha isbeddelkan ay ka mid yihiin isbeddellada cuntada, isbeddelka qaabdhismeedka flora mindhicirka, hoos u dhaca dhaqdhaqaaqa polyamine synthase, iwm.

Bartilmaameedka dabiiciga ah ee shahwada

Waa maxay sababta molecule yar oo fudud u yahay walaxda muhiimka u ah jidhka bini'aadamka? Sirtu dhab ahaantii waxay ku jirtaa qaab-dhismeedkeeda: Spermidine waa amine polycationic (-NH3+) dufan yar oo ka jira qaab-protonated badan oo hoos yimaada xaaladaha pH-ga jireed, oo leh ions togan oo loo qaybiyay dhammaan silsiladda kaarboon. Kharashka korantada, wuxuu leeyahay dhaqdhaqaaq jireed oo xooggan.

Sidaa darteed, haddii ay tahay asiidhyada nucleic, fosfolipids, borotiinno acidic ah oo ay ku jiraan haraaga acidic, polysaccharides pectic oo ay ku jiraan kooxaha karboxyl iyo sulfates, ama neurotransmitters iyo hormoonnada (dopamine, epinephrine, serotonin, hoormoonka tayroodh, iwm) oo leh qaabab isku mid ah, Waxay suurtogal u tahay bartilmaameedka spermidine. xirid. Kuwa ugu xasaasisan waa:

① Nucleic acid:

Daraasaduhu waxay ogaadeen in polyamines-yada intooda badani ay ku jiraan qaabka polyamine-RNA ee unugyada gudaha, oo leh 1-4 oo u dhiganta polyamine ku xidhan 100kii u dhigma ee xeryahooda fosfatetada. Sidaa darteed, doorka ugu muhiimsan ee shahwadadu waxay la xiriirtaa isbeddellada qaabdhismeedka iyo tarjumaada RNA, sida saameyn ku yeelashada heerarka kala duwan ee borotiinka iyadoo saameynaysa qaabka labaad ee mRNA, tRNA iyo rRNA. Spermidine waxay sidoo kale samayn kartaa "buundooyin" deggan oo u dhexeeya xargaha DNA-da laba-helical, yaraynta helitaanka xag-jirrada xorta ah ama walxaha kale ee waxyeelada u leh DNA, iyo ka ilaalinta DNA-da kuleylka kuleylka iyo shucaaca raajada.

②Borootiin:

Spermidine waxay ku xidhmi kartaa borotiinada sidda kharashyo taban oo waaweyn waxayna beddelaan is-waafajinta boosaska borotiinka, taasoo saamaynaysa shaqadiisa jir ahaaneed. Tusaalooyinka waxaa ka mid ah kinases protein / fosfatas (isku xirka muhiimka ah ee dariiqyada gudbinta calaamadaha badan), enzymes ee ku lug leh histone methylation iyo acetylation (oo saameeya muujinta hidda-wadaha iyadoo la beddelayo epigenetics), acetylcholinesterase (qayb muhiim ah oo ka mid ah cudurrada neurodegenerative). mid ka mid ah daawooyinka daweynta), ion channel reseptors (sida AMPA, AMDA reseptors), iwm.

Suzhou Myland waa shirkad ka diiwaan gashan FDA oo bixisa budada Spermidine tayo sare leh oo nadiif ah.

Suzhou Myland, waxaa naga go'an inaan ku bixinno alaabada ugu tayada wanaagsan qiimaha ugu fiican. Budadayada Spermidine si adag ayaa loogu tijaabiyaa daahirnimada iyo awoodda, iyadoo la hubinayo inaad hesho kabitaan tayo sare leh oo aad ku kalsoonaan karto. Haddii aad rabto in aad taageerto caafimaadka gacanta, kor u qaado habka difaacaaga ama aad xoojiso caafimaadka guud, budadayada Spermidine waa doorashada ugu fiican.

Iyada oo leh 30 sano oo waayo-aragnimo ah oo ay dhaqaajisay tignoolajiyada sare iyo istaraatiijiyad R&D aadka loo hagaajiyay, Spermidine waxay soo saartay badeecooyin tartan ah oo kala duwan si ay u noqdaan kabitaan saynis nololeed oo cusub, isku-dubarid caado ah iyo shirkad adeegyo wax soo saar ah.

Intaa waxaa dheer, Suzhou Myland sidoo kale waa soo-saare ka diiwaan gashan FDA. Khayraadka R&D ee shirkadda, agabka wax-soo-saarka, agabka falanqayntu waa kuwo casri ah oo hawl-badan leh, waxayna awood u leeyihiin inay soo saaraan kiimikooyin min milligram ilaa tan oo miisaan ahaan ah, waxayna u hoggaansamaan heerarka ISO 9001 iyo qeexida wax-soo-saarka GMP.