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4 Kaabayaasha Kahortagga Gabowga ee ugu Sareeya ee lagu Hagaajinayo Caafimaadka Mitochondrial: keebaa Xoog badan?

Saynis yahanadu waxay ogaadeen in marka aan da'danahay, mitochondria-yagu si tartiib tartiib ah hoos ugu dhaco oo ay soo saaraan tamar yar. Tani waxay u horseedi kartaa cudurrada da'da la xiriira sida cudurrada neerfayaasha, cudurrada wadnaha, iyo kuwo kale.

Urolitin A

Urolitin A waa dheef-shiid kiimikaad dabiici ah oo leh antioxidant iyo saameyn lid ku ah proliferative. Khubaro dhanka nafaqada ah oo ka socda jaamacadda Nova Southeast University ee dalka Maraykanka ayaa daahfuray in isticmaalka urolitin A sida faragelinta cuntada ay dib u dhigi karto geedi socodka gabowga iyo ka hortagga horumarinta cudurada la xidhiidha da'da.
Urolithin A (UA) waxaa soo saara bakteeriyada mindhicirka ka dib markii ay cuntay polyphenols laga helo cuntooyinka sida rummaanka, strawberries, iyo walnuts. Kaabista UA ee jiirarka da'da dhexe waxay kicisaa sirtuins waxayna kordhisaa NAD + iyo heerarka tamarta gacanta. Muhiimad ahaan, UA ayaa la muujiyay inay ka nadiifiso mitochondria dhaawacan muruqyada bini'aadamka, taas oo hagaajinaysa xoogga, caabbinta daalka, iyo waxqabadka ciyaaraha fudud. Sidaa darteed, kabidda UA waxay kordhin kartaa cimriga iyadoo ka hortagaysa gabowga muruqa.
Urolithin A si toos ah ugama iman cuntada, laakiin xeryahooda sida ellagic acid iyo ellagitannins ee ku jira lawska, rummaannada, canabka iyo miraha kale waxay soo saari doonaan urolithin A ka dib markii ay dheefshiidaan microorganisms mindhicirka.

spermidine

Spermidine waa nooc dabiici ah oo ka mid ah polyamine-ka oo helay fiiro gaar ah sannadihii la soo dhaafay awooddeeda ay ku kordhiso cimriga iyo kordhinta caafimaadka. Sida NAD + iyo CoQ10, shahwadu waa unug dabiici ah oo soo baxa oo hoos u dhaca da'da. Si la mid ah UA, spermidine waxaa soo saara bakteeriyada mindhicirkeena waxayna kicisaa mitophagy - ka saarida mitochondria aan caafimaad qabin, dhaawacan. Daraasadaha jiirka ayaa muujinaya in kabidda spermidine ay ka ilaalin karto cudurrada wadnaha iyo gabowga taranka haweenka. Intaa waxaa dheer, shahwada cuntada (laga helo cuntooyin kala duwan oo ay ku jiraan soy iyo miro) waxay wanaajisay xusuusta jiirarka. Cilmi baaris dheeraad ah ayaa loo baahan yahay si loo go'aamiyo in natiijooyinkan lagu soo celin karo aadanaha iyo in kale.
Habka gabowga ee caadiga ah wuxuu yareeyaa fiirsashada qaababka dabiiciga ah ee shahwada ee jirka, sida laga soo xigtay cilmi-baaris lagu daabacay Warbixinnada Sayniska ee cilmi-baarayaasha Kyoto Prefectural University of Medicine ee Japan. Si kastaba ha ahaatee, dhacdadan laguma arag qarniyadii;
Spermidine waxay kor u qaadi kartaa autophagy.
Cuntooyinka ay ku badan tahay shahwadu waxay ka kooban tahay: cuntooyinka qamadiga oo dhan, kelp, boqoshaada shiitake, lawska, bracken, purslane, iwm.

Hal qayb oo ka mid ah Suzhou Myland Pharm & Nutrition Inc.

curcumin
Curcumin waa xarun firfircoon oo ku jirta turmeric kaas oo leh sifooyin anti-bararka iyo antioxidant.
Cilmi-baarayaal ku takhasusay cilmiga bayoolajiga oo ka socda Akademiyada Sayniska ee Polish ayaa ogaaday in curcumin uu yarayn karo calaamadaha gabowga oo uu dib u dhigo horumarka cudurrada da'da la xidhiidha kuwaas oo unugyadu ay si toos ah ugu lug leeyihiin, taas oo kordhinaysa cimriga.
Kasokow ka sakow, cuntooyinka ay ku badan tahay curcumin-ku waxa ka mid ah: Sinjibiisha, toonta, basasha, basbaaska madow, khardal iyo curry.

NAD+ kaabista
Meesha ay jiraan mitochondria, waxaa jira NAD + (nicotinamide adenine dinucleotide), molecule lagama maarmaanka u ah sare u qaadida wax soo saarka tamarta. NAD + si dabiici ah ayey hoos ugu dhacdaa da'da, taas oo u muuqata mid la socota hoos u dhaca da'da ee shaqada mitochondrial. Tani waa mid ka mid ah sababaha NAD + xoojiyayaasha sida NR (Nicotinamide Ribose) loo sameeyay si loo soo celiyo heerarka NAD +.
Cilmi baaris ayaa muujisay in kor u qaadista NAD +, NR ay kor u qaadi karto wax soo saarka tamarta mitochondrial iyo ka hortagga cadaadiska da'da. Kaabayaasha horudhaca ah ee NAD+ ayaa laga yaabaa inay wanaajiyaan shaqada murqaha, caafimaadka maskaxda, iyo dheef-shiid kiimikaadka iyadoo ay suurtagal tahay inay la dagaallamaan cudurrada neurodegenerative. Intaa waxaa dheer, waxay yareeyaan korodhka miisaanka, waxay hagaajiyaan dareenka insulinta, waxayna caadi ka dhigaan heerarka dufanka, sida hoos u dhigista kolestaroolka LDL.


Waqtiga boostada: Jul-24-2024