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Faa'iidooyinka 7,8-Dihydroxyflavone ee Shaqada Maskaxda iyo Xusuusta

7,8-Dihydroxyflavone waa iskudhis si dabiici ah u soo baxa oo laga helo dhirta taas oo heshay fiiro gaar ah faa'iidooyinka suurtagalka ah ee shaqada maskaxda iyo xusuusta. Xaruntan flavone-ka waxa iska leh nooc kiimikooyin ah oo loo yaqaan flavonoids, kuwaas oo loo yaqaanno antioxidant-ka iyo sifooyinka caabuqa. Cilmi baaris ayaa muujisay in 7,8-dihydroxyflavone laga yaabo inay saameyn wanaagsan ku yeelato maskaxda.

7,8-Dihydroxyflavone waa iskudhis awood leh oo isku dhafan oo ka tirsan qoyska flavonoid. Flavonoids waa isku-dhisyo dabiici ah oo si ballaaran ugu qaybsan dhirta waxayna ka ciyaaraan door muhiim ah hababka noole ee kala duwan. Mid ka mid ah tayada cajiibka ah ee 7,8-dihydroxyflavone waa awoodda ay u leedahay inay la falgasho oo ay maamusho borotiinnada iyo enzymes-ka jirka, taas oo kicisay xiisaha weyn ee bulshada sayniska.

Waa maxay 7,8-Dihydroxyflavone

Cilmi baaris ayaa muujisay in xarunta 7,8-dihydroxyflavone ay leedahay faa'iidooyin caafimaad oo suurtagal ah, lehna antioxidant, anti-bararka iyo guryaha neuroprotective. Waxaa ka mid ah, firfircoonida xooggan ee antioxidant ee 7,8-dihydroxyflavone waxay awood u siineysaa inay ka takhalusto xag-jirrada xorta ah ee waxyeellada leh ee jirka waxayna ka hortagtaa diiqada oksaydhka inay keento dhaawaca unugyada iyo cudurrada kala duwan. Cilmi-baarista ilaa hadda lagu sameeyay 7,8-dihydroxyflavones waa dhiirigelin, laakiin cilmi-baaris dheeraad ah ayaa loo baahan yahay si loo go'aamiyo waxtarka iyo badbaadada 7,8-dihydroxyflavones si loogu isticmaalo bini'aadamka. Si kastaba ha ahaatee, xaruntan flavonoid waxa ay haysaa ballan qaad weyn oo ah kabitaan cunto ama musharraxa daroogada mustaqbalka.

 

 

Faa'iidooyinka 7,8-Dihydroxyflavone

 

7,8-Dihydroxyflavone waa xarun dabiici ah, oo sidoo kale loo yaqaan 7,8-DHF, taas oo heshay dareen badan sanadihii ugu dambeeyay faa'iidooyinka suurtagalka ah ee caafimaadka aadanaha.

Xaruntan si dabiici ah u dhacda waxa iska leh qoyska flavonoid waxaana laga helaa dhir kala duwan, oo ay ku jiraan xididka Scutellaria baicalensis.

Faa'iidooyinka 7,8-Dihydroxyflavone

1. Hagaajinta shaqada garashada

Cilmi-baaristu waxay muujineysaa in xaruntani ay u shaqeyso sidii agonist TrkB, taasoo la macno ah inay dhaqaajiso soo-dhoweynta TrkB ee maskaxda. Receptors-yadani waxay mas'uul ka yihiin kor u qaadida korriinka iyo badbaadada neerfayaasha, iyo sidoo kale kor u qaadida balaastikada synaptik - awoodda maskaxdu si ay ula qabsato oo wax u beddesho. Iyada oo la kicinayo reseptors TrkB, 7,8-dihydroxyflavone ayaa la muujiyey inay hagaajiso xusuusta iyo garashada. Tani waxay ka dhigaysaa wakiilka daweynta ee suurtogalka ah ee lagu daaweynayo cudurrada neerfayaasha sida cudurka Alzheimers.

2. Saamaynta ka hortagga niyad-jabka

Iyada oo la hawlgelinayo soo-dhoweynta TrkB, xaruntu waxay kor u qaadaysaa korriinka neerfayaasha cusub ee hippocampus, aagga maskaxda ee ku lug leh xakamaynta niyadda. Daraasadaha moodooyinka xayawaanku waxay muujiyeen in 7,8-dihydroxyflavone ay yarayn karto calaamadaha niyad-jabka iyo kor u qaadida iska caabinta walaaca. Natiijooyinkani waxay soo jeedinayaan in xaruntan loo isticmaali karo beddelka dabiiciga ah ee dawooyinka niyad-jabka ee dhaqameed.

3. Qalabka anti-bararka iyo awoodda antioxidant

7,8-Dihydroxyflavone waa antioxidant awood leh oo ka caawiya ka ilaalinta unugyada cadaadiska oksaydhka ee ay sababaan xagjirrada xorta ah. Ilaalintani waxay yaraynaysaa halista cudurada daba dheeraada waxayna hoos u dhigtaa habka gabowga.

Caabuqa maskaxda ayaa laga yaabaa inuu gacan ka geysto horumarinta iyo horumarinta cudurrada neerfaha ee kala duwan, oo ay ku jiraan cudurka Parkinson iyo sclerosis badan. Cilmi-baaristu waxay muujinaysaa in 7,8-DHF ay leedahay sifooyin anti-bararka kuwaas oo gacan ka geysanaya dhimista bararka maskaxda iyo ka hortagga neurodegeneration. Iyadoo la joojinayo soo saarista molecules pro-inflammatory, xaruntu waxay yeelan kartaa awood ay ku yareyso calaamadaha oo ay hoos u dhigto horumarka cuduradan daciifka ah.

4. Waxa uu suurtogal u yahay in lagu daweeyo xanuunada welwelka

Daraasadaha xayawaanku waxay muujiyeen in xaruntu ay yarayn karto habdhaqanka walaaca leh iyada oo la hawlgelinayo soo-dhoweynta TrkB ee amygdala, oo ah aagga maskaxda ee ku lug leh jawaabaha cabsida iyo walaaca. Iyada oo la beddelayo dhaqdhaqaaqa soo-dhoweeyayaashan, 7,8-dihydroxyflavones ayaa laga yaabaa inay bixiso hab dabiici ah oo wax ku ool ah oo lagu maareeyo walaaca iyada oo aan waxyeellooyinka la xidhiidha daawooyinka dhaqameed ee ka hortagga walaaca.

Waa maxay cuntooyinka ku jira7,8-dihydroxyflavone?

Kahor intaanan u galin ilaha cuntada, aynu fahano waxa 7,8-dihydroxyflavone runtii yahay. Waa flavonoid dabiici ah oo ka tirsan fasalka flavonoids. Flavonoids waa xayndaabyada dhirta ku salaysan ee loo yaqaan 'antioxidant properties', kuwaas oo ka caawiya inay unugyada ka ilaaliyaan xagjirrada xorta ah ee waxyeellada leh.

Haddaba, aan sahaminno cuntooyinka ay ku jiraan xaddi badan oo ah 7,8-dihydroxyflavone:

Cuntooyinkee ka kooban 7,8-dihydroxyflavone?

1. Miraha liinta

Mid ka mid ah ilaha ugu wanaagsan ee 7,8-dihydroxyflavones waa miraha liinta sida liinta, liinta, canabka iyo liinta. Mirahani maaha oo kaliya qani ku ah fitamiin C, laakiin sidoo kale waxaa ku jira noocyo kala duwan oo flavonoids ah, oo ay ku jiraan 7,8-dihydroxyflavone.

2. Berry

Berry sida blueberries, strawberries, raspberries, iyo blackberries waxay caan ku yihiin maadada antioxidant sare. Mirahan macaan ayaa sidoo kale ah il weyn oo 7,8-dihydroxyflavone ah, taasoo ku siinaya labanlaab faa'iidooyinka caafimaadka.

3. Shukulaatada madow

War wanaagsan oo loogu talagalay dadka jecel shukulaatada! Shukulaatada madow, gaar ahaan mid ka kooban kookaha, ayaa ka kooban xaddi badan oo ah 7,8-dihydroxyflavonoids. Si kastaba ha ahaatee, dooro noocyo leh qadarka ugu yar ee sonkorta lagu daray si aad u hesho faa'iidooyinka buuxa.

4. Shaah cagaaran

Marka laga soo tago inuu yahay cabitaan caan ah, shaaha cagaaran wuxuu sidoo kale qani ku yahay flavonoids, oo ay ku jiraan 7,8-dihydroxyflavone. Isticmaalka joogtada ah ee shaaha cagaaran waxay kaa caawin kartaa inaad kordhiso qaadashadaada antioxidant waxayna taageertaa caafimaadka guud.

5. Soy

Haddii aad raadinayso isha dhirta ee 7,8-dihydroxyflavone, soy waa doorasho weyn. Ma aha oo kaliya inay ku badan yihiin borotiinka, laakiin sidoo kale waxay ka kooban yihiin flavonoids kala duwan kuwaas oo gacan ka geysta hantidooda faa'iidada leh.

6. Khudaarta caleenta cagaaran

Khudaarta sida kaluunka, isbinaajka, iyo broccoli kuma koobna oo kaliya kalooriyada, laakiin sidoo kale qani ku ah antioxidants. Cagaarkan caleenta ahi waa il heer sare ah oo laga helo 7,8-dihydroxyflavone, iyo sidoo kale nafaqooyinka kale ee muhiimka ah.

7. Khamriga cas

Farxad! Cabitaanka dhexdhexaadka ah ee khamriga cas waxa ku jira nooc flavonoid ah oo loo yaqaan resveratrol, oo ay ku jiraan 7,8-dihydroxyflavone. Xaruntan ayaa loo malaynayaa inay gacan ka geysato faa'iidooyinka wadnaha iyo xididdada dhiigga ee la xidhiidha isticmaalka khamriga cas ee dhexdhexaadka ah.

Ku darista cuntooyinkan cuntadaada waxay ku siin kartaa faa'iidooyin badan oo la xidhiidha 7,8-dihydroxyflavone.

 Is 7,8-dihydroxyflavoneammaan ah?

 
7,8-dihydroxyflavone badbaado ma yahay?

7,8-Dihydroxyflavone, oo sidoo kale loo yaqaan DHF ama baicalein, waa flavonoid si dabiici ah u dhaca oo laga helo dhir kala duwan, oo ay ku jiraan xididka Scutellaria baicalensis. Xaruntani waxay heshay dareen badan sanadihii ugu dambeeyay faa'iidooyinka caafimaad ee suurtagalka ah iyo sifooyinka daaweynta. Si kastaba ha ahaatee, marka la tixgelinayo badbaadada walax kasta, waxaa muhiim ah in la baaro caddaynta sayniska ee la hayo. Haddaba, 7,8-dihydroxyflavone badbaado ma yahay?

 

Marka la eego ammaankeeda, cilmi-baaris xaddidan ayaa lagu sameeyay isticmaalka tooska ah ee aadanaha ee 7,8-dihydroxyflavone. Sidaa darteed, samaynta bayaan dhammaystiran oo ku saabsan ammaankeeda waa caqabad. Si kastaba ha ahaatee, daraasadaha xayawaanku waxay bixiyeen aragti qiimo leh oo ku saabsan sunta suurtagalka ah. Noocyo kala duwan oo xayawaan ah ayaa soo sheegay wax saameyn ah oo la taaban karo ka dib maamulka DHF, xitaa qiyaaso sarreeya. Tani waxay soo jeedinaysaa in 7,8-dihydroxyflavone si fiican loogu dulqaadan karo, ugu yaraan gudaha xuduudaha la darsay.

Si kastaba ha ahaatee, taxaddar waa in la sameeyaa marka la soo saarayo gabagabada ku saleysan kaliya daraasaadka xayawaanka. Saamaynta maaddooyinka ayaa si weyn u kala duwanaan kara inta u dhexeysa noocyada, sidaa darteed, taxaddar ayaa loo baahan yahay marka natiijada loo soo saaro aadanaha. Waxaa intaa dheer, la'aanta daraasado bini'aadminimo oo dhammaystiran oo muddada dheer ah ayaa ka hortagay in si cad loo qiimeeyo ammaankeeda.

Qiyaasta iyo Talooyinka loogu talagalay7,8-dihydroxyflavoneor

 

7,8-Dihydroxyflavone (7,8-DHF) waa flavonoid si dabiici ah u dhacda kaas oo helay fiiro gaar ah faa'iidooyinka caafimaad ee suurtogalka ah, si kastaba ha ahaatee, aad bay muhiim u tahay in la ogaado qiyaasta iyo talooyinka lagu taliyey marka la isticmaalayo 7,8-DHF muhiim ah.

Waa muhiim inaad la tashato xirfadle daryeel caafimaad marka ay timaado qiyaasta 7,8-DHF, maadaama qiyaasta ku habboon ay ku kala duwanaan karto arrimo badan sida da'da, miisaanka iyo xaalado caafimaad oo gaar ah. Daraasadda hadda jirta waxay soo jeedinaysaa xulashooyin kala duwan oo qiyaas ah, sida caadiga ah 20 ilaa 60 mg maalintii. Si kastaba ha ahaatee, waa in la ogaadaa in talooyinkan aan la dhigin dhagax oo laga yaabo inay isbeddelaan marka la soo ururiyo caddayn cilmiyeed oo badan.Qiyaasta iyo talada 7,8-dihydroxyflavoneor

Markaad iibsanayso 7,8-DHF supplements cunto, waa lama huraan inaad doorato soo-saare sumcad leh oo la aamini karo si loo hubiyo badbaadada iyo waxtarka alaabta. Akhrinta dib u eegista macaamiisha iyo hubinta shaybaadhka qolo saddexaad waxay sidoo kale caawin kartaa go'aaminta isku halaynta alaabta. Aad bay muhiim u tahay inaad raacdo talada xirfadlahaaga daryeelka caafimaadka. Waxay awoodi doonaan inay bixiyaan hagitaan shaqsiyeysan oo ku saleysan taariikhdaada caafimaad iyo xaaladaha caafimaad ee hadda jira. Had iyo jeer waxaa lagu talinayaa in lagu bilaabo qiyaasta ugu waxtarka badan ee ugu hooseeya oo si tartiib tartiib ah loo kordhiyo sida loogu baahan yahay kormeerka xirfadlaha daryeelka caafimaadka.

Kahor intaadan ku darin 7,8-DHF nidaamkaaga maalinlaha ah, waa muhiim inaad ka digtoonaato waxyeelo kasta oo iman karta ama isdhexgalka daroogada. In kasta oo 7,8-DHF guud ahaan si wanaagsan loo dulqaatay, dadka qaar ayaa laga yaabaa inay la kulmaan calool xanuun fudud ama dareen-celin xasaasiyadeed. Sidoo kale, hubi inaad u sheegto xirfadlahaaga daryeelka caafimaadka wixii daawooyin ah ama kaabyo ah oo aad hadda qaadanayso si aad uga fogaato wax kasta oo is dhexgal ah. Xusuusnow in qaadashada kaabis kasta ay tahay inay had iyo jeer hoos timaado jihada xirfadlaha daryeelka caafimaadka si kor loogu qaado caafimaadkaaga.

S: Muddo intee le'eg ayay qaadanaysaa 7,8-dihydroxyflavoneor inuu shaqeeyo?

J: Xawaaraha uu 7,8-dihydroxyflavone (7,8-DHF) saamayn ku yeesho wuu kala duwanaan karaa iyadoo ku xidhan dhawr arrimood. Daraasadaha sayniska, 7,8-DHF waxay muujisay inay leedahay saameyno kala duwan, sida kor u qaadida sii deynta neurotrophic iyo neuroprotection. Wakhtiga ay qaadanayso saamayntan si ay u muujiyaan waxay u dhaxayn kartaa saacado ilaa maalmo ama xitaa ka badan, taas oo ku xidhan qaabka gaarka ah ee ficilka iyo bartilmaameedka xarunta.

Afeef: Maqaalkani waxa loogu talagalay ujeeddooyin macluumaad oo keliya mana aha in loo tixgeliyo talo caafimaad. Had iyo jeer la tasho xirfadle daryeel caafimaad ka hor intaadan isticmaalin wax kaabis ah ama bedelin nidaamka daryeelka caafimaadkaaga.


Waqtiga boostada: Jul-04-2023