5-amino-1-methylquinolinium iodide CAS No.: 42464-96-0 98.0% daahirnimo min. | kaabista maaddooyinka soo saaraha
Qiyaasta Alaabta
| Magaca alaabta | 5-amino-1-methylquinolinium iodide |
| Magac kale | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| CAS Maya. | 42464-96-0 |
| qaacidada molecular | C10H11IN2 |
| Miisaanka molecular | 286.11 |
| daahirnimo | 98% |
| Muuqashada | Brown ilaa guduud adag oo bunni ah |
| Baakad | 1kg/bac, 25kg/fuusto |
| Codsiga | Kaabista Cunnada Qalabka Ceyriinka ah |
hordhaca alaabta
NNMTi waa enzim aad loo buunbuuniyay inta lagu jiro gabowga murqaha lafaha waxayna la xiriirtaa hagaajinta dhaawaca dariiqa NAD +, waxqabadka sirtuin1 oo aan nidaamsaneyn, iyo korodhka dareenka unugyada tarma ee muruqa. NNMTi waxay kor u qaadaa kala duwanaanshaha myoblast ee vitro waxayna wanaajisaa fiyuuska iyo dib u soo kabashada unugyada tarma muruqa ee jiirarka da'da ah. NNMTi sidoo kale waa horjooge awood leh ee nicotinamide N-methyltransferase (NNMT) (IC50=1.2 μM), si xushmad leh ugu xidha NNMT hadhaaga goobta isku xidhka substrate. NNMTi waxay kor u qaadaa kala duwanaanshaha myoblast ee vitro waxayna wanaajisaa fiyuuska iyo dib u soo kabashada unugyada tarma muruqa ee jiirarka da'da ah. Waxaa ka mid ah, enzyme cytosolic nicotinamide N-methyltransferase (NNMT) ayaa dhawaan la helay si loo habeeyo heerarka nicotinamide horudhacyada looga baahan yahay NAD + biosynthesis, sidaas darteed waxay door muhiim ah ka ciyaartaa nidaaminta dariiqa badbaadada NAD + iyo dheef-shiid kiimikaadka gacanta.
Muuqaal
(1) Nadaafadda sare: NNMTi waxay ku heli kartaa badeecooyin nadiif ah oo sarreeya iyada oo loo marayo hababka wax soo saarka ee la safeeyey. Nadaafadda sare waxay ka dhigan tahay helitaan noole oo wanaagsan.
(2) Bartilmaameedka: NNMTi waxay si gaar ah u bartilmaameedsanaysaa enzyme NNMT waxayna si wax ku ool ah u joojin kartaa hawsheeda, taas oo saameynaysa dariiqa dheef-shiid kiimikaadka ee nicotinamide.
(3) Xasilooni: NNMTi waxay leedahay xasillooni wanaagsan waxayna sii wadi kartaa dhaqdhaqaaqeeda iyo saameynteeda hoos yimaada deegaan iyo xaalado kaydin oo kala duwan.
(4) Horumarinta rajada: Sababo la xiriira sifooyinka kala duwan ee NNMT, horumarinteedu waxay heshay fiiro gaar ah waxayna leedahay cilmi-baaris ballaaran iyo rajooyin codsi.
Codsiyada
NNMTi waa nicotinamide N-methyltransferase (NNMT) inhibitor kaas oo kor u qaada kala duwanaanshaha myoblast. NNMTi sidoo kale waxaa loo isticmaali karaa kabitaan ahaan si loo yareeyo miisaanka iyo baruurta iyo hagaajinta baruurta beerka.
