Taurine waa nafaqeeyayaalka yar yar ee muhiimka ah iyo aminosulfonic acid oo badan. Waxa si weyn loogu qaybiyaa unugyo iyo xubno kala duwan oo jidhka ah. Waxay inta badan ku jirtaa xaalad xor ah oo ku jirta dareeraha interstitial iyo dareeraha unugyada. Sababtoo ah waxay markii hore ku jirtay Magaca ka dib markii laga helay biilka dibida. Taurine waxaa lagu daraa cabitaannada caadiga ah ee shaqada si ay u buuxiyaan tamarta una hagaajiyaan daalka.
Dhawaan, cilmi-baaris ku saabsan taurine ayaa lagu daabacay saddexda joornaal ee ugu sarreeya Sayniska, Unugga, iyo Dabeecadda. Daraasadahan ayaa shaaca ka qaaday shaqooyinka cusub ee taurine - ka hortagga gabowga, hagaajinta saameynta daaweynta kansarka, iyo ka hortagga buurnaanta.
Bishii Juun 2023, cilmi-baarayaal ka socda Machadka Qaranka ee Immunology ee Hindiya, Jaamacadda Columbia ee Mareykanka, iyo machadyo kale ayaa daabacay waraaqo joornaalka tacliinta sare ee caalamiga ah ee Sayniska. Daraasadu waxay soo jeedinaysaa in taurine yaraanta ay tahay darawalka gabowga. Kaabista taurine waxay hoos u dhigi kartaa gabowga nematodes, jiirarka, iyo daayeerrada, waxayna xitaa kordhin kartaa cimriga caafimaadka qaba ee jiirarka da'da dhexe 12%. Faahfaahin: Sayniska: Awood ka baxsan male-awaalkaaga! Taurine sidoo kale waxay beddeli kartaa gabowga oo kordhin kartaa cimriga?
Bishii Abriil 2024, Professor Zhao Xiaodi, Associate Professor Lu Yuanyuan, Professor Nie Yongzhan, iyo Professor Wang Xin oo ka socda Isbitaalka Xijing ee Jaamacadda Caafimaadka Militariga ee Afraad ayaa ku daabacay waraaqo joornaalka tacliinta sare ee caalamiga ah ee Cell. Daraasadani waxay ogaatay in unugyada burooyinka ay kula tartamayaan unugyada CD8+ T ee taurine iyagoo si xad dhaaf ah u buufiyay gaadiidka taurine SLC6A6, taas oo keenta dhimashada unugyada T-ga iyo daal, taasoo keenta baxsashada difaaca burada, taas oo kor u qaadeysa horumarka burada iyo soo noqoshada, iyada oo kordhinta Taurine ay dib u soo celin karto unugyada CD8+ T ee daalay. iyo hagaajinta waxtarka daaweynta kansarka.
Agoosto 7, 2024, kooxda Jonathan Z. Long ee Jaamacadda Stanford (Dr. Wei Wei waa qoraagii ugu horreeyay) ayaa daabacay warqad cilmi-baaris ah oo cinwaan looga dhigay: PTER waa N-acetyl taurine hydrolase kaas oo nidaamiya quudinta iyo buurnaanta ee tacliinta sare ee caalamiga ah. joornaalka Nature.
Daraasadani waxay daahfurtay N-acetyl taurine hydrolase-kii ugu horreeyay ee naasleyda, PTER, waxayna xaqiijisay doorka muhiimka ah ee N-acetyl taurine ee dhimista qaadashada cuntada iyo ka hortagga buurnaanta. Mustaqbalka, waxaa suurtagal ah in la horumariyo kuwa awoodda leh ee PTER-ka ah ee la xushay daaweynta buurnaanta.
Taurine waxaa si weyn looga helaa unugyada naasleyda iyo cuntooyin badan waxaana laga helaa xaddi sare oo gaar ahaan unugyo xamaasad leh sida wadnaha, indhaha, maskaxda, iyo murqaha. Taurine ayaa lagu tilmaamay inay leedahay hawlo unugyo kleiotropic ah iyo hawlo nafsiyeed, gaar ahaan marka la eego macnaha homeostasis-ka dheef-shiid kiimikaadka. Dhimista hidda-socodka ee heerarka taurine waxay keenaysaa atrophy muruqa, hoos u dhaca awoodda jimicsiga, iyo cilladda mitochondrial ee unugyo badan. Kaabista taurine waxay yaraynaysaa diiqada redox mitochondrial, waxay wanaajisaa awooda jimicsiga, waxayna xakamaysaa miisaanka jidhka.
Biochemistry iyo enzymology ee dheef-shiid kiimikaadka taurine ayaa soo jiitay cilmi-baaris la taaban karo. Dariiqa biosynthetic ee endogenous taurine, cysteine waxaa metabolized by cysteine dioxygenase (CDO) iyo cysteine sulfinate decarboxylase (CSAD) si loo soo saaro hypotaurine, taas oo ka dib Oxidation by flavin monooxygenase 1 (FMO1) soo saartaa taurine. Intaa waxaa dheer, cysteine waxay dhalin kartaa hypotaurine iyada oo loo marayo dariiqa kale ee cysteamine iyo cysteamine dioxygenase (ADO). Hoos-u-dhaca taurine laftiisa ayaa ah dhowr metabolites taurine labaad, oo ay ku jiraan taurocholate, tauramidine, iyo N-acetyl taurine. Enzymeska kaliya ee loo yaqaan inuu kiciyo waddooyinkan hoose waa BAAT, kaas oo isku daraya taurine iyo bile acyl-CoA si loo soo saaro taurocholate iyo cusbada kale ee bile. Marka lagu daro BAAT, aqoonsiga molecular ee ensaymesyada kale ee dhexdhexaadinaya dheef-shiid kiimikaad taurine ah ayaan wali la go'aamin.
N-acetyltaurine (N-acetyl taurine) waa mid xiiso gaar ah leh laakiin si liidata loo bartay metabolite sare ee taurine. Heerarka N-acetyl taurine ee dareerayaasha bayoolojiga waxaa si firfircoon u habeeya khalkhal badan oo nafsiyeed oo kordhiya socodka taurine iyo/ama acetate, oo ay ku jiraan jimicsiga adkeysiga, isticmaalka khamriga, iyo nafaqada taurine. Intaa waxaa dheer, N-acetyltaurine waxay la mid tahay qaabdhismeedka kiimikaad ee moodooyinka calaamadaha oo ay ku jiraan neurotransmitter acetylcholine iyo silsiladda dheer ee N-fatty acyltaurine kaas oo nidaamiya sonkorta dhiigga, taasoo soo jeedinaysa in ay sidoo kale u shaqeyn karto sida dheef-shiid kiimikaad ah Alaabta ayaa shaqeysa. Si kastaba ha ahaatee, biosynthesis, hoos u dhaca, iyo hawlaha suurtagalka ah ee N-acetyl taurine ayaan weli caddayn.
Daraasaddan ugu dambeysay, kooxda cilmi-baaristu waxay aqoonsadeen PTER, ensaymes agoonka ah oo aan la garanaynin shaqada, sida naasleyda weyn ee N-acetyl taurine hydrolase. In vitro, dib-u-habaynta PTER waxay soo bandhigtay kala duwanaansho substrate cidhiidhi ah iyo xaddidaadyo waaweyn. Gudaha N-acetyl taurine, waxa lagu shubaa taurine iyo acetate.
Ku-dhufashada hidda-wadaha Pter-ka ee jiirarka waxay keentaa luminta dhammaystiran ee N-acetyl taurine hydrolytic dhaqdhaqaaqa unugyada iyo kororka habaysan ee N-acetyl taurine content ee unugyo kala duwan.
Goobta PTER ee bini'aadamka waxay la xiriirtaa index mass index (BMI). Kooxda cilmi-baaristu waxay sii ogaadeen in ka dib kicinta heerarka taurine ee kordhay, jiirarka Pter knockout waxay muujiyeen qaadashada cuntada oo yaraatay waxayna u adkeysanayaan cayilka cuntada. iyo gulukoosta homeostasis oo hagaagtay. Kaabista N-acetyl taurine ee cayilka nooca duurjoogta ah ayaa sidoo kale hoos u dhigtay qaadashada cuntada iyo miisaanka jidhka qaab ku tiirsan GFRAL.
Xogtaasi waxay PTER ku dhigtaa xuddunta enzyme-ka ee dheef-shiid kiimikaadka sare ee taurine waxayna muujisaa doorka PTER iyo N-acetyl taurine ee xakamaynta miisaanka iyo dheelitirka tamarta.
Guud ahaan, daraasaddan ayaa daahfurtay acetyl taurine hydrolase ugu horeysay ee naasleyda, PTER, waxayna xaqiijisay doorka muhiimka ah ee acetyl taurine si loo yareeyo qaadashada cuntada iyo ka hortagga buurnaanta. Mustaqbalka, waxaa la filayaa in kuwa awood leh oo la xushay PTER inhibitors loo sameeyo daaweynta buurnaanta.
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Waqtiga boostada: Agoosto-12-2024
